catalyze synthesis of rRNA
alpha helix, zinc finger, helix turn helix catalyze histone acetylation/deacetylation, recruit coactivators and corepressors.
a-amanitin
inhibit elongation, intercalated near G residue
synthesis hnRNA (nuclear RNA)
patient who present with flushing, high blood calcitonin level, exhibit alternative mRNA splicing
Alpha Thalassemia Both fetus (HbF) and (HbA), defective remodeling and spacing protein
Betal Thalassemia in Ch 11
makes antibodies to DNA and SnRNA-binding protein
Amanita Phalloides
inhibit RNA pol II
Butterfly shaped rash. Systemic Lupus Erythematosus
Actinomycin D
Death cap mushroom inhibit pol II and III, microfilament are stabilized . gastric lavage.
RNA polymerase I
Transcription Factors
RNA polymerase II
Medullary Thyroid Cancer
result from hnRNA Splicing defect, hnRNA Cap site defect, poly(A) signal defect.
Defect on Ch. 16
