A patient has liver and kidney disease. He is given a medication with a half-life of 30 hours. The nurse expects the duration of this medication to...
A.
Increase
B.
Decrease
C.
Remain Unchanged
D.
Dissipate
2.
When assessing older adults and those with renal dysfunction, the nurse knows that creatinine clearance is usually
A.
substantially increased
B.
slightly increased
C.
decreased
D.
in the normal range
3.
Which nursing actions would be most appropriate for ensuring patient safety with a medication that has a low therapeutic index?
A.
monitoring a pts urine output
B.
assessing vital signs hourly
C.
maintaining strict isolation precautions
D.
monitor serum peak and trough levels
4.
Most drugs are metabolized in the
A.
kidney
B.
small intestine
C.
liver
D.
brain
5.
A patient sustains significant burns to the skin and is experiencing fluid shift associated with edema in the fluid overload phase. The nurse would anticipate that this will interfere most with which phase of pharmacodynamics?
A.
Absorption
B.
Distribution
C.
Metabolism
D.
Excretion
6.
The nurse recognizes that the administration of a drug influences cell physiology. What is the term for this concept?
A.
Pharmacokinetics
B.
Pharmacotherapeutics
C.
Pharmacodynamics
D.
Pharmacology
7.
Which statement best indicates that the nurse understands the meaning of pharmacokinetics?
A.
“It involves the study of physiologic interactions of drugs.”
B.
“It explains the distribution of the drug between various body compartments.”
C.
“It explains interactions between various drugs.”
D.
“It explains the adverse reactions to drugs.”
8.
The nurse is administering an injection to a patient and wants the medication to take effect as quickly as possible. Which injection site will the nurse select?
A.
Sub Q
B.
Ventrogluteal
C.
Deltoid
D.
Dorsogluteal
9.
The pharmacist states that the patient’s biotransformation of a drug was altered. The nurse interprets this to mean that
A.
absorption has affected the drug.
B.
dilution has affected the drug.
C.
excretion has affected the drug.
D.
metabolism has affected the drug.
10.
A nurse is administering two highly protein-bound drugs to the patient. Which is the safest course of action for the nurse to take?
A.
Assess the patient frequently for the risk of drug-drug interactions
B.
Administer the drugs with food
C.
Administer the drugs with 8 ounces of water.
D.
Assess baseline liver function tests
11.
he patient is scheduled to receive an enteric-coated tablet immediately after a meal. The nurse will choose which food to include as part of the patient’s meal?
A.
Hot Dogs
B.
Avocados
C.
Salami
D.
Skim Milk
12.
The nurse has administered several oral medications to the patient. Which factors will influence the absorption of these medications? (Select all that apply.)
A.
Presence of food in the stomach
B.
pH of the stomach
C.
Patient position upon intake of medication
D.
Form of drug preparation
E.
Pain
F.
Amount of saliva
13.
By which route would the nurse expect bioavailability to be greater?
A.
Oral
B.
IV
C.
Transdermal
D.
SubQ
14.
Which drugs can effectively cross the Blood Brain Barrier?
A.
Water Soluble
B.
Protein Bound
C.
IV
D.
Lipid Soluble
15.
Which type of receptor interaction act on a number of different receptors, and cause many different effects ?
A.
Nonselective
B.
Antagonist
C.
Agonist
D.
Selective
16.
Why is a loading dose given?
A.
to achieve rapid minimum effective concentration
B.
to avoid toxicity
C.
to obtain optimal serum levels
D.
to avoid drug tolerance
17.
Which of the following is the definition of a reaction caused by pharmacogenetic difference?
