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Bilirubin ( Hepatitis ) ( Not often on test ) :

Bilirubin is a product of red blood cell ____________________ . Serum levels are used to test the severity and the progress of jaundice . An increase in serum bilirubin is commonly associated with increased red blood cell ____________________ or by liver disease .

Direct ? if the bilirubin has a chance to go to the liver and get conjugated it becomes water soluble . This is known as ? direct reacting bilirubin ? and an increase usually indicates the presence of a biliary ____________________ .

Indirect ? When bilirubin doesn't get to the liver , it doesn't become water soluble , thus it is unconjugated or indirect . If this type of bilirubin is elevated , one should suspect excess red blood cell ____________________ .

Normals : 0 . 1 - 1 . 0 mg / ml

Increased In : Direct ? ____________________ , hepatic duct obstruction

Indirect - ____________________ disease



Bun ( Blood Urea Nitrogen ) : This is the chief end product of amino acid metabolism , formed by the liver . It is excreted in urine and comprises about ½ of the urinary solids .

Normals : 8 - 25 mg / 100ml

Increased In : starvation , ____________________ disease , dehydration , hypotension , chronic ____________________ , urinary tract ____________________

____________________ In : hepatic insufficiency , hepatic failure , pregnancy



Calcium ( Serum ) :

Calcium , as well as phosphorus , are stored in the bone and are constantly exchanged with blood and tissue fluids . Vitamin D and parathormone influence this process . Vitamin D is needed for ____________________ absorption of calcium . Parathormone increases the rate of bone ____________________ with mobilization of calcium and phosphorus from bone . Milk and milk by products supply most of the dietary calcium . 99% of the calcium in the body is found in the bones and the teeth . Calcium is found in the body in both the ionized form and the protein bound form . The ionized form functions in the activation of ____________________ in blood clotting , in muscle ____________________ and in the transmission of nerve impulses . A ____________________ serum level of calcium causes tetany .

Normals : 9 - 11mg%

Increased In : ____________________ , bone metastasis , hypervitaminosis , D ____________________ , ____________________

Decreased In : ____________________ , malabsorption , vitamin D ____________________ , acute pancreatitis , renal failure , malnutrition



CEA ( Carcinoembryonic Antigen ) :

A glycoprotein that is normally present in the GI tissues of the fetus and normally secreted into the lumen of the GI tract in the adult . These levels are high in biliary tract obstruction , alcoholic hepatitis , heavy smoking , and ____________________ of the GO tract , lungs and breast . When used in conjunction with other methods the test seems to be useful as an indicator for the progress in the treatment for many cancers . The serum level seems to fall to normal within one month of treatment .

Normals : 5 . 0 mg / ml



Coombs Test :

This is used to detect anti red cell ____________________ in the body . It is normally negative . Positive reactions are found in ____________________ diseases of the newborn , autoimmune hemolytic anemia , etc .



CPK ( SGOT / AKA AST and LDH ) :

Creatine phosphokinase is present almost exclusively in ____________________ muscle , ____________________ muscle , and in brain tissue . It enters the circulation quickly after atrophy or ____________________ of the cells .

One of the most valuable tests to indicate the occurrence of an ____________________ .

It increases 50 - 100 times the normal level 4 - 6 hours after an MI .

It peaks 30 hours later .

It returns to normal in 2 - 3 days .

In muscular dystrophies the values will be ____________________ 300 - 400 times normal .

Isoenzymes : CK1 BB : brain tissue

CK2 MB : myocardial tissue

CK3 MM : skeletal muscle

Normals : Males = 5 - ____________________ u / ml : Females 5 - ____________________ u / ml



Creatinine : ( Best test for ____________________ function )

An end product of the normal metabolism of phosphocreatine utilized for muscle energy . It is a nitrogenous compound secreted in the ____________________ . This level does not vary with diet , so it is a very valuable indicator of ____________________ function .

Normals : 0 . 7 - 1 . 5 mg / ____________________ ml

Increased In : chronic ____________________ , obstructive uropathy , ____________________ shock .

Decreased In : muscular dystrophies



CRP : ( Any time there is ____________________ )

C - reactive protein is not normally present in a patient's blood . It appears in the presence of inflammation , and is an earlier indicator of ____________________ than an ESR . It is best used to evaluate the course and severity of ____________________ necrosis .

Present In : It is present in acute rheumatic fever , ____________________ arthritis , malignancy , acute ____________________ and viral infections .



ESR :

The erythrocyte sedimentation rate refers to the amount of red blood cells that fall to the bottom of a test tube in one hour . ____________________ and necrosis of tissue causes RBC's to aggregate and become heavier . The heavier the cell , the faster it falls . The cells are made heavier by ____________________ produced by the body in ____________________ states .

Normals : Males = 0 = 15 : Females 0 - 20

Increased In : ____________________ , inflammatory disease , ____________________ , multiple myeloma , temporal arteritis , and all ____________________ diseases



FTA :

The Fluorescent Treponema Antibody Test is sensitive and specific for ____________________ . It is best used when definite syphilis symptoms are present , yet other tests show negative results .



Glucose ( Blood ) :

Blood sugar is formed from carbohydrates and stored in the liver as glycogen . Slight elevations are said to be of questionable significance . This test is done in the fasting state and is diagnostic of diabetes mellitus if ____________________ consecutive fasting blood sugar tests are over ____________________ mg% .

Normals : 80 - ____________________

Increased In : diabetes mellitus , acute emotional or physical disturbnaces , ____________________ , pancreatitis , chronic renal or liver disease

Decreased In : overdose of insulin , ____________________ disease , starvation , liver damage ( alcoholism ) , and pancreatic islet cell carcinoma

Glucose ( Blood ) Postprandial :

This is a blood sugar test taken ____________________ hours after eating a high carbohydrate meal . In normal people the blood sugar returns to normal within 2 hours .

Increased In : Diabetes

Glucose ( GSF ) :

The CSF glucose is usually ____________________ percent of blood glucose . Blood glucose is drawn 1 hour prior to a spinal tap . Changes in blood sugar are seen in the CSF 1 - 3 hours later .

Normals : 50 - ____________________ mg / dl

Decreased In : acute pyogenic infections , ____________________



GGT :

Referred to as gamma - glutamyl transferase or gamma - glutamyl transpeptidase . It is an enzyme found mainly in the liver , kidney , spleen and prostate . This enzyme is normally higher in males because of large amounts found in the prostate . The test is used to determine liver cell ____________________ and ____________________ induced liver disease .

Used to screen for chronic alcoholism , to monitor the cessation of alcohol consumption and all forms of liver disease .

This test is more sensitive in detecting ____________________ jaundice , cholangitis and cholecystitis than alkaline phosphatase or transaminase tests .



Glucose Tolerance Test ( GTT ) :

The patient is instructed to fast ____________________ hours before theis procedure . A blod sample is drawn to determine the fasting blood glucose level . A glucose solution ( Glucola ) is given orally , and blood samples are drawn at ½ hour , 1 hour and each hour thereafter for a total of ____________________ hours .

1 . Normal

2 . Mild Diabetes

3 . Severe Diabetes

4 . Functional Hypoglycemia

5 . Organic or Endocrine Hypoglycemia

Note : The GTT is potentially ____________________ , especially for uncontrolled diabetics , persons taking hormones , salicylate , diuretics , anti seizure drugs , or birth control pills .