Prototype: Diazepam (Valium)
Action: binds to selective serotonin receptor sites to cause vasoconstriction of cranial vessels.
Action: Inhibits presynaptic reuptake of norepi & serotonin; anticholinergic at CNS & peripheral receptors, sedating.
Prototype: Phenobarbital (generic)
Prototype: Ergotamine (Ergomar)
Action: Acts in limbic system & RAS to potentiate effects of GABA, an inhibitory neurotransmitter; may act in SC & suprasternal sites to produce muscle relaxation.
Action: Inhibits conduction in ascending RAS; depresses cerebral cortex; alters cerebellar function; depresses motor output
Prototype: Sumatriptan (Imitrex)
Action: Blocks alpha-adrenergic & serotonin receptor sites in brain: constriction of cranial vessels.
Prototype: Imipramine (Tofranil)
Indications: tx of anxiety disorders, alcohol w/drawal, hyperexcitability/agitation, preop relief of anxiety/tension.
Indications: Tx for acute migraines & cluster HAs
Indication: relief of depression symptoms
Indications: sedation; tx of insomnia; tx of seizures; preanesthetic.
Indication: tx of migraines or vascular HAs
