Action: Irreversibly inhibits MAO, allowing norepi, 5HT, & dopamine to accumulate in synaptic cleft.
Action: Inhibits CNS neuronal reuptake of 5HT (increases levels of 5HT in synaptic cleft), w/little effect on norepi.
Prototype: Clozapine (Clozaril)
Prototype: Chlorpromazine (Thorazine)
Indication: May alleviate some of the unpleasant neurological effects and depression of typical antipsychotics.
Action: Blocks both dopamine receptors & serotonin receptors.
Action: Primarily dopamine receptor blockers
Action: CNS stimulants act as cortical & RAS stimulants, possibly by increasing release of catecholamines from presynaptic neurons. Mild cortical stimulant.
Indication: Tx for depression in those unresponsive to other antidepressive therapy.
Prototype: Lithium (Lithobid)
AEs: Causes several adverse effects including hypotension, anticholinergic effects, and extrapyramidal side effects (EPS)
Indication: Tx of depression, OCDs, panic attacks, bulimia, PTSD, social phobias, social anxiety d/o’s.
Prototype: Methylphenidate (Ritalin, Concerta)
Action: Alters sodium transport in nerve & muscle cells; inhibits release of norepi & dopamine but not serotonin.
Indication: Narcolepsy, attention deficit d/o.
Indication: Tx of manic episodes of bipolar d/o's & maintenance tx of bipolar d/o's.
Prototype: Phenelzine (Nardil)
Prototype: Fluoxetine (Prozac)
