Histologic
characteristics
The
definition
____________________
Barrett
esophagus
(
BE
)
has
evolved
considerably
over
the
____________________
100
years
.
In
1906
,
Tileston
,
a
pathologist
,
described
____________________
patients
with
"
peptic
ulcer
of
____________________
oesophagus
"
in
which
the
epithelium
around
the
ulcer
closely
resembled
that
normally
____________________
in
the
stomach
.
The
debate
for
the
next
4
____________________
centered
on
the
anatomic
origin
of
this
mucosal
____________________
.
Many
investigators
,
including
Barrett
in
his
treatise
published
____________________
1950
,
supported
the
view
that
this
ulcerated
,
columnar
-
lined
____________________
was
,
in
fact
,
the
stomach
tethered
within
the
____________________
by
a
congenitally
short
esophagus
.
In
1953
,
Allison
____________________
Johnstone
argued
that
the
columnar
organ
was
more
____________________
esophagus
,
because
the
intrathoracic
region
lacked
a
peritoneal
____________________
,
contained
submucosal
glands
and
muscularis
propria
characteristic
of
____________________
esophagus
,
and
could
harbor
islands
of
squamous
cells
____________________
the
columnar
segment
.
In
1957
,
Barrett
agreed
and
____________________
that
the
condition
that
bears
his
name
29
/
11
/
2018
Barrett
Esophagus
:
Practice
Essentials
,
Background
,
Etiology
be
____________________
____________________
as
"
lower
esophagus
lined
by
columnar
epithelium
.
"
____________________
the
next
2
decades
,
descriptions
of
the
histology
____________________
Barrett
esophagus
varied
considerably
from
acid
-
secreting
,
fundic
-
type
epithelium
to
intestinal
-
type
epithelium
with
goblet
cells
.
Finally
,
in
1976
,
Paull
et
al
published
a
report
on
the
histologic
spectrum
of
Barrett
esophagus
in
which
they
used
manometric
guidance
for
their
biopsies
.
The
study's
patients
had
1
or
a
combination
of
3
____________________
of
columnar
epithelium
;
ie
,
a
gastric
fundic
-
type
,
a
junctional
type
,
____________________
a
distinctive
type
of
intestinal
metaplasia
the
investigators
called
"
specialized
columnar
epithelium
.
"
This
____________________
intestinal
metaplasia
(
SIM
)
,
complete
with
____________________
cells
,
has
____________________
the
sine
qua
non
for
the
diagnosis
of
Barrett
esophagus
.
