Chronic syndromes:
Chronic presentation:
History:
Acute syndromes:
Acute/subacute presentation:
Clinical course:
Antigen testing:
Location:
CBC count:
Serology:
Sex/race/ethnicity:
Immunosuppressed presentation:
Physical examination:
Adenopathy:
Midwestern United States, Southeastern United States, Central America, Eastern Canada
Cavitary lung lesions
Thrombocytopenia in disseminated disease
Cavitary pulmonary lung disease, calcified lymph nodes, mediastinal fibrosis
Lung infiltrate, lobar pneumonia, micronodular pattern
Large exposure includes construction sites, birds, caves; low exposure includes living in an endemic area
Uncommon findings include erythema nodosum and erythema multiforme
Usually asymptomatic (if symptoms occur they are nonspecific); symptoms 3 months indicate chronic disease
Pneumonia, disseminated disease in immunocompromised persons
Diffuse disease.
Common, granulomatous mediastinal involvement, can be profound, can calcify
Useful in testing immunocompetent individuals with acute or subacute disease.
Useful in testing infiltrative or chronic disease in immunosuppressed; urine antigen has ~60% sensitivity; serum antigen has ~60% sensitivity; both combined have >80% sensitivity
No predisposition
