Severe uncontrolled hypertension (unresponsive to emergency therapy)
Traumatic or prolonged (>10 min) CPR
Known structural cerebral vascular leeson
Ischaemic stroke within 6 months, EXCEPT acute ischaemic stroke within 4.5 hours
Major surgery (<3 weeks)
Active peptic ulcer
Recent (within 2 to 4 weeks) internal bleeding
Oral anticoagulant therapy
Suspected aortic dissection
Active bleeding or bleeding diathesis (excluding menses)
