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1. The main reasons for treating symptoms of the menopausal transition and actual menopause are as follows:
2. In the Women’s Health Initiative (WHI), greater safety and possible benefit from hormone or estrogen therapy for women in their 50s, with potential harm for older women, were observed with respect to the following
3. Administration routes for hormone therapy are as follows:
4. Contraindications for estrogen therapy include the following:

To provide relief of vasomotor symptoms

Vaginal route cream, ring, or tablet for vaginal symptoms

Total mortality

Severe liver disease

To avoid the irregularity of menstrual cycles

Pregnancy

Venous thrombosis

Colorectal cancer

To preserve bone

Topical

To lower the risk of disease

Oral

Transdermal

Total myocardial infarction

Personal history of breast cancer

Global index of chronic diseases

To reduce the risk of unwanted pregnancy

Undiagnosed vaginal bleeding

To improve quality of life

Coronary artery disease (CAD)