The
pathogenesis
of
corneal
ulcers
____________________
with
autoinflammatory
diseases
is
____________________
clear
.
Possibilities
include
immunologic
responses
to
____________________
antigens
and
genetic
susceptibility
,
such
as
genetic
predisposition
____________________
the
development
of
defective
suppressor
T
-
lymphocyte
function
,
production
of
autoantibodies
(
eg
,
antinuclear
antibodies
)
,
and
activation
of
the
complement
pathway
.
Peripheral
ulcerative
keratitis
(
PUK
)
is
a
rare
manifestation
of
RA
characterized
____________________
a
progressive
thinning
of
the
peripheral
cornea
secondary
to
release
of
collagenases
____________________
proteases
by
neutrophils
and
/
or
macrophages
and
complement
activation
in
the
region
of
the
limbal
vasculature
and
avascular
cornea
.
This
____________________
to
keratolysis
,
with
____________________
without
ulceration
.
