Pemphigus
herpetiformis
appears
to
be
mediated
____________________
the
immunoglobulin
G
(
IgG
)
class
of
autoantibodies
that
target
the
skin
epidermis
desmoglein
components
.
Most
patients
demonstrate
autoantibodies
____________________
desmoglein
1
,
a
desmosomal
component
predominantly
____________________
in
the
upper
epidermis
,
while
a
minority
of
patients
demonstrates
autoantibodies
to
desmoglein
3
,
which
is
predominantly
located
in
the
lower
epidermis
,
and
,
most
recently
,
desmocollin
.
____________________
ability
of
desmoglein
3
to
induce
____________________
experimental
model
____________________
pemphigus
after
transfer
of
splenocytes
from
desmoglein
3
-
immunized
desmoglein
3
-
knockout
mice
to
Rag
-
2
immunodeficient
mice
further
supports
the
role
of
desmogleins
as
autoantigens
.
Histologically
____________________
eosinophil
and
/
or
neutrophil
infiltration
____________________
the
epidermis
may
be
relevant
pathogenically
in
the
disease
process
of
pemphigus
herpetiformis
.
