Corticosteroids (eg, hydrocortisone, dexamethasone)
Early recognition
Early hemodynamic resuscitation and continued support
Volume expanders (eg, albumin)
Alpha-/beta-adrenergic agonists (eg, norepinephrine, dopamine, dobutamine, epinephrine, vasopressin, phenylephrine)
Maintain adequate organ system function, guided by cardiovascular monitoring, and interrupt the progression of MODS
Proper ventilator management with low tidal volume in patients with acute respiratory distress syndrome (ARDS)
Identify the source of infection and treat with antimicrobial therapy, surgery, or both (source control)
Start adequate antibiotics (proper spectrum and dose) as early as possible
Resuscitate the patient from septic shock by using supportive measures to correct hypoxia, hypotension, and impaired tissue oxygenation (hypoperfusion)
Antibiotics (eg, cefotaxime, ticarcillin-clavulanate, piperacillin-tazobactam, imipenem-cilastatin, meropenem, clindamycin, metronidazole, ceftriaxone, ciprofloxacin, cefepime, levofloxacin, vancomycin)
Isotonic crystalloids (eg, normal saline, lactated Ringer solution)
Synthetic human angiotensin II
Source control
Early and adequate antibiotic therapy
