AE
Nav 1.7
PK/PD
GMT
SCONE model
Ames Test
PO
QD
IL10
MDCK
FDA
CDX/PDX
FTE
FEP
RLM
kinetic solubility
Colo205
IP
WaterMap
DMPK
BID
IC50
ROCK1
LM
Treg
DDI Study
ADME
CYP
HLM
OCI-LY3/OCI-LY10
hERG Test
RRCK
DDR
(nude) BALB c mice
AUC
NSCLC
SW48
SAR
(anrti) PD1 and (anti) PD-L1
TGI model
MET-ID Study
nude mice have a mutation that causes their lack of fur which also makes them have insufficient immune responses - useful to not reject implanted tumors; having both types (nude and not) can serve as comparison/controls
model mammalian cell line (canine)
Drug-Drug Interaction study; studies that are performed to assess the effects/safety of using the potential drug candidate in parallel with other medications
protein; Serine/Threonine kinase; key regulator of actin cytoskeleton and cell polarity
concentration of a compound in solution at the time when an induced precipitate first appears (similar to saturating solution)
Drug Metabolism and Pharmaco-kinetics; safety evaluation of drug candidates: includes categories like bioavailability, half-life, clearance, and metabolic profile; more preclinical
Human Liver Microsome; used in DMPK studies
Ralph Russ Canine Kidney; cell permeability assay
Full Time Equivalent; employee that works at a CRO to do ongoing wet lab work for Schrödinger
once per day, referring to dosing
Interleukin 10; anti-inflammatory cytokine, used as a PD marker
Human Ether-a-go-go Related Gene; toxicity study related to cardiac function
Food and Drug Administration; governing body in US for drug approval
patient derived cell line: colorectal adenocarcinoma
Rat Liver Microsome; used in DMPK studies
Schrödinger software that allows visualization and calculations of the energy of water molecules solvating the binding site of a protein
one ion channel peptide chain being investigated in complex with GMTs
Tumor Growth Inhibition model; T/C: tumor volume in control versus treated mice at a specified time; comparing the rate of growth of treated versus untreated tumors in an animal model
uses bacteria to test whether a given chemical can cause mutations in the DNA of the test organism; more formally, it is a biological assay to assess the mutagenic potential of chemical compounds
Diffuse Large B-Cell Lymphoma cell lines
Area Under the (plasma drug concentration) Curve; reflects the actual body exposure to drug after administration of a dose of the drug; dependent on the rate of elimination of the drug from the body and the dose administered; low AUC = high clearance
software tool used for performing predictive simulations in modeling
Cell-Derived Xenograft/Patient-Derived Xenograft; human tumor samples are cultured as cell lines and implanted into mouse models to test the efficacy of anti-tumor compounds in vivo
Gating Modifier Toxin; venom derived peptides that affect ion channels
in prescriptions, delivered by mouth
Absorption, Distribution, Metabolism, and Excretion; used in PK studies to describe the behavior/activity of a drug in the body
patient derived cell line: colorectal adenocarcinoma
Adverse Event; negative event observed in studies or treatment
Free Energy Perturbation; program used to predict "drugability" characteristics using Schrödinger softwares; compared to actual data in development; physics based method
Intellectual Property; agreements in collaboration deals so that information cannot be stolen
programmed cell death protein; programmed cell death ligand; protein on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity
Liver Microsome; either human or animal, used as a treatment model
Pharmaco-Kinetic/Pharmaco-Dynamic modeling; pharmacokinetics describes the drug concentration-time courses in body fluids resulting from administration of a certain drug dose; pharmacodynamics is the observed effect resulting from a certain drug concentration; more in humans
Non-Small Cell Lung Cancer; common indication specifically in EGFR/KRAS pathway related studies
DNA Damage Repair
twice per day, referring to dosing
Regulatory T cells; used in studies to measure immune response and disease progression
Structure-Activity Relationship; used to predict biological activity from molecular/chemical structure
cytochromes; class of proteins important for clearance metabolism
Half maximum Inhibitory Condition; according to the FDA, this represents the concentration of a drug that is required for 50% inhibition in vitro
Metabolite Identification study; study to investigate the metabolism of the potential DC and explore why DC is being cleared too slowly/quickly
