Types of Cardiac DrugsOnline version PharmSci 401: Match the generic cardiac drug with the proper class of drug. by Rachael Lange 1 Cardiac Drug Class 1 2 Cardiac Drug Class 2 3 Cardiac Drug Class 3 4 Group 4 treat essential HTN C: sedation, depression, reound HTN Centrally Acting Sympatholytics M: sedation, lassitude, hepatotoxicity, hemolytic anemia alpha-2 agonists @ central receptors, decr. vasc. resist., decr. C.O., decr. sympathetic output CLONIDINE, METHYLDOPA Peripherally Acting Sympatholytics affects postgang. neurons of PSNS. [G: displace. of norepi. from granules & inhibit. of release of norepi.] & [R: depletion of catecholamines from granules] 2nd line treatment of HTN G: orthostatic Hypotension R: can cause depression because can cross BBB GUANETHIDINE, RESERPINE Cannot use w/Sympathomimetics OTC (cold meds.=decongestants). Activate sensitive alpha-receptors. Trycyclic antidepressants prevent uptake of G. into neurons. PRAZOSIN Andrenergic Antagonists: alpha-blockers P: alpha-1 specific blocker [alpha-1 receptor blockade causes relax. of smooth muscle & decr. vasc. resist.) **Substantial 1st pass effects, still useful orally w/adjusted dose. treat HTN P: first dose response (severe hypotension in response to 1st dose), depression, fatigue, fluid retention Andrenergic Antagonists: beta-blockers (class II antidysrhythymic) competitive inhibition of beta-receptors, decr. C.O., & decr. vasc. resist. **1st pass effect Essential HTN Ischemic Heart Disease HF Cardiac Arrythymias
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