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John Snow

William Farr

James Lind

John Graunt

Richard Doll & Austin Bradford Hill

Experimental studies on Scurvy; eradication in British Navy

"perfect model" of epidemiological research; Cholera outbreak solved through observations, a natural experiment, and quantitative analysis

Controlled clinical trials; Tuberculosis; Smoking/ Lung cancer study

Statistical abstracts for General Registry Great Britain; inferences about population through vital statistics; standardized mortality rate

Bills of Mortality; weekly count of deaths; patterns of fertility, disease and death