Fill in the Blanks Tumor Lysis Syndrome Fill in the BlanksOnline version Fill in the Blanks game about Tumor Lysis Syndrome with key information and terms by Melissa Reason 1 bloodstream hematologic malignancies benign tumors liver failure rapidly urine treatment hematologic imbalances solid tumors leukemia monitoring kidney failure slowly Tumor lysis syndrome is a potentially life - threatening complication experienced by patients with cancer . It occurs when a large number of cancer cells are destroyed , leading to the release of their contents into the . This can overwhelm the body's ability to clear these substances , resulting in electrolyte imbalances , , and other serious complications . Tumor lysis syndrome most commonly occurs in patients with , such as and lymphoma , but can also occur in . Prompt recognition and are essential to prevent severe complications and improve outcomes . 2 normal acidic any alkaline decreased extensive elevated Patients with cancer may have baseline risk factors . Patients with white blood cell counts are one example . Patients with alterations in renal function , including urine output and urine , also are at an increased risk . Additionally , patients who have lymph node involvement are more prone to developing tumor lysis syndrome . 3 72 4-8 24 complete blood count 8-12 metabolic panel Laboratory parameters to be monitored include a . Labs should be evaluated every hours during the first hours of cancer treatment . 4 greater greater less greater less less less greater When reviewing laboratory results for a patient experiencing tumor lysis syndrome , the nurse would expect the following : Uric acid - than 8mg / dl Potassium - than 6mEq / L Phosphorus - than 4 . 5mg / dl Calcium - than 7mg / d l 5 Hydration with IV fluids Hydration with oral fluids Monitoring medications Monitoring lab value Strategies to prevent tumor lysis syndrome include : Diuretics Diet modification