In
____________________
,
the
World
Health
____________________
declared
that
smallpox
(
variola
virus
)
had
been
____________________
successfully
worldwide
.
The
United
States
____________________
routine
childhood
immunization
against
smallpox
in
1972
and
routine
immunization
of
health
care
professionals
in
1976
.
Following
eradication
,
2
World
Health
____________________
reference
laboratories
were
authorized
to
maintain
stocks
of
variola
virus
.
In
2003
,
the
United
States
initiated
a
____________________
smallpox
immunization
program
for
first
responders
to
facilitate
preparedness
and
response
to
a
possible
smallpox
bioterrorism
event
.
____________________
infected
with
variola
develop
a
severe
prodromal
illness
characterized
by
____________________
fever
,
malaise
,
severe
____________________
,
backache
,
abdominal
pain
.
Infected
children
can
suffer
from
vomiting
and
seizures
during
this
____________________
period
.
Most
patients
with
smallpox
are
severely
ill
and
____________________
during
the
febrile
prodrome
.
The
prodromal
period
is
followed
by
development
of
lesions
on
mucosa
of
the
mouth
or
pharynx
.
This
stage
occurs
less
than
____________________
hours
before
onset
of
rash
,
which
is
usually
the
first
recognized
manifestation
of
____________________
.
With
onset
of
oral
lesions
,
the
patient
becomes
infectious
and
remains
so
until
all
skin
crust
lesions
have
separated
.
The
rash
typically
begins
on
the
face
and
rapidly
progresses
to
involve
the
forearms
,
trunk
,
and
legs
.
Lesions
increase
in
size
for
approximately
8
to
10
____________________
after
which
they
begin
to
crust
.
Once
all
the
crusts
have
separated
,
3
to
4
____________________
after
the
onset
of
rash
,
the
patient
is
no
longer
infectious
.
Varicella
(
chickenpox
)
is
the
condition
most
likely
to
be
mistaken
for
smallpox
.
Generally
,
____________________
with
varicella
do
not
have
a
febrile
prodrome
,
but
____________________
can
have
a
brief
,
mild
prodrome
.
Although
the
2
diseases
are
confused
easily
in
the
first
few
days
of
the
rash
,
smallpox
lesions
develop
into
pustules
that
are
firm
and
deeply
embedded
in
the
dermis
,
whereas
varicella
lesions
develop
into
superficial
vesicles
.
____________________
varicella
erupts
in
crops
of
lesions
that
evolve
quickly
,
lesions
on
any
one
part
of
the
____________________
will
be
in
different
stages
of
____________________
(
papules
,
vesicles
,
and
crusts
)
,
whereas
all
smallpox
lesions
on
any
one
part
of
the
body
are
in
the
same
stage
of
development
.
