Enzyme InhibitionOnline version 2 types of enzyme inhibition by Dr MAHABOOB KHAN SULAIMAN 1 Competitive Inhibition 2 Non-competitive Inhibitor Substrate has similar shape as inhibitor Both substrate and inhibitor try to bind to the active site Inhibition can be reversed when subtrate is at very high levels Many drugs used as medicines work by this mechanism Inhibitor binds at allosteric site on the enzyme Inhibitor binding alters 3D shape of enzyme making it unsuitable for substrate binding can poison the enzyme permanently Inhibitor binding may covalently alter a functional group on the enzyme
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