Matching Pairs Cholesterol pharmacologyOnline version Cholesterol pharmacology by Ashleigh Pell 1 What statins do, and where 2 most potent statin 3 statin indication 4 statin side effects 5 statin with less drug interactions 6 statin warning 7 What does the enzyme HMG-CoA do? 8 standard statin 9 with less cholesterol synthesis, what does the liver do? pravastatin Grapefruit inhibits cytochrome P450, increasing statin bioavailability. myalgia/headache/GI symptoms simvastatin increases hepatic synthesis of cholesterol inhibit HMG-CoA reductase in the liver high lipids / LDL increases the uptake of low-density lipoprotein (LDL) from the blood atorvastatin 1 Fenofibrate indication 2 fenofibrate caution 3 ezetimisbe side effect 4 ezetimibe inhibits 5 Alirocumab side effects 6 Alirocumab inhibits 7 alirocumab indication 8 fenofibrate causes lipolysis because 9 fenofibrate activates 10 fenofibrate contra-indication 11 fenofibrate side effects inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors high serum triglycerides GI upset/vomiting weakness/GI upset/headaches PPARα's genes code for peroxisomes which participate in lipolysis familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective flu-like symptoms nuclear receptor PPARα which begins gene transcription and translation intestinal cholesterol absorption myotoxicity if improper dose or renal impairment. gall bladder disease, pancreatitis
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