Matching Pairs Cholesterol pharmacologyOnline version Cholesterol pharmacology by Ashleigh Pell 1 statin with less drug interactions 2 What does the enzyme HMG-CoA do? 3 standard statin 4 statin warning 5 with less cholesterol synthesis, what does the liver do? 6 statin side effects 7 What statins do, and where 8 statin indication 9 most potent statin Grapefruit inhibits cytochrome P450, increasing statin bioavailability. increases the uptake of low-density lipoprotein (LDL) from the blood atorvastatin simvastatin pravastatin myalgia/headache/GI symptoms increases hepatic synthesis of cholesterol high lipids / LDL inhibit HMG-CoA reductase in the liver 1 fenofibrate causes lipolysis because 2 alirocumab indication 3 fenofibrate contra-indication 4 fenofibrate activates 5 ezetimisbe side effect 6 ezetimibe inhibits 7 fenofibrate caution 8 Alirocumab inhibits 9 Alirocumab side effects 10 Fenofibrate indication 11 fenofibrate side effects myotoxicity if improper dose or renal impairment. gall bladder disease, pancreatitis weakness/GI upset/headaches flu-like symptoms PPARα's genes code for peroxisomes which participate in lipolysis high serum triglycerides familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective GI upset/vomiting intestinal cholesterol absorption nuclear receptor PPARα which begins gene transcription and translation inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors
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