Matching Pairs Cholesterol pharmacologyOnline version Cholesterol pharmacology by Ashleigh Pell 1 What statins do, and where 2 What does the enzyme HMG-CoA do? 3 statin with less drug interactions 4 standard statin 5 with less cholesterol synthesis, what does the liver do? 6 statin warning 7 statin side effects 8 statin indication 9 most potent statin high lipids / LDL simvastatin inhibit HMG-CoA reductase in the liver Grapefruit inhibits cytochrome P450, increasing statin bioavailability. increases the uptake of low-density lipoprotein (LDL) from the blood pravastatin myalgia/headache/GI symptoms increases hepatic synthesis of cholesterol atorvastatin 1 fenofibrate caution 2 fenofibrate contra-indication 3 ezetimisbe side effect 4 alirocumab indication 5 Alirocumab side effects 6 Fenofibrate indication 7 Alirocumab inhibits 8 fenofibrate side effects 9 fenofibrate activates 10 fenofibrate causes lipolysis because 11 ezetimibe inhibits gall bladder disease, pancreatitis PPARα's genes code for peroxisomes which participate in lipolysis myotoxicity if improper dose or renal impairment. familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective weakness/GI upset/headaches inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors flu-like symptoms intestinal cholesterol absorption high serum triglycerides nuclear receptor PPARα which begins gene transcription and translation GI upset/vomiting
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