Matching Pairs Cholesterol pharmacologyOnline version Cholesterol pharmacology by Ashleigh Pell 1 statin warning 2 statin side effects 3 most potent statin 4 statin indication 5 statin with less drug interactions 6 What statins do, and where 7 with less cholesterol synthesis, what does the liver do? 8 What does the enzyme HMG-CoA do? 9 standard statin increases hepatic synthesis of cholesterol simvastatin increases the uptake of low-density lipoprotein (LDL) from the blood Grapefruit inhibits cytochrome P450, increasing statin bioavailability. atorvastatin pravastatin inhibit HMG-CoA reductase in the liver myalgia/headache/GI symptoms high lipids / LDL 1 fenofibrate activates 2 fenofibrate side effects 3 Fenofibrate indication 4 fenofibrate causes lipolysis because 5 ezetimibe inhibits 6 ezetimisbe side effect 7 fenofibrate contra-indication 8 Alirocumab side effects 9 fenofibrate caution 10 alirocumab indication 11 Alirocumab inhibits familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective myotoxicity if improper dose or renal impairment. gall bladder disease, pancreatitis nuclear receptor PPARα which begins gene transcription and translation PPARα's genes code for peroxisomes which participate in lipolysis inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors intestinal cholesterol absorption weakness/GI upset/headaches high serum triglycerides flu-like symptoms GI upset/vomiting
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