Matching Pairs Chapter 17 Innate, nonspecific Host DefensesOnline version chapter 17 vocabulary by Janet Marticorena 1 Physical barriers 2 Plasma contains: 3 Chemical barriers 4 Adaptive response 5 Immunity 6 Serum contains: 7 purpose of immune system 8 Innate response surveillance of the body, recognition of foreign invaders and material, destruction of foregin invaders complement proteins, antibodies, molecules not related to defense stomach acid, lysozyme, low ph from ear wax and fatty acids clotting factors, complement proteins, antibodies skin, mucus membranes, cilia, flushing, reflexes, normal flora/ microbiome barriers, eliminators, chemical components b cells, t cells, chemical components a state of having sufficient biological defenses to avoid infection, disease or other unwanted biological invasion 1 PRR 2 Neutrophils 3 Cytokines 4 PAMPs 5 Alveolar macrophage 6 Monocyte 7 Microglial in the brain most abundant white blood cell in the blood, engulf and destroy bacteria, uses NETS, make pus formation signaling molecules secreated by many different immune cells in the lungs pathogen-associated molecular patterns, things on the exterior part of pathogen that cause a response pattern recognition receptor, receptors on phagocytic cells that recognize PAMPs, Toll-like receptors in the blood 1 3 2 2- 3 1- injured/infected cells secrete chemical signals into the blood, what happend next? the leukocytes squeeze between the cells of the capillary wall as they follow the chemical signals to where they are most concentrated neutrophils releases cytotoxic chemicals from granules into tissue leukocytes in the blood respond to chemical attractants released by pathogens and chemical signal from nearby injured cells 1 Swelling 2 Redness 3 exogenous pyrogens 4 Pain 5 endogenous pyrogens 6 Warmth you trigger it, our own cells trigger it (rubor) due to lots of blood to the area (calor) because the blood comes from the core (tumor) because all the extra volume pathogen trigger or something else trigger it (dolor) the nerves become pinched 1 Natural killer cells 2 3 ways to activate complement system 3 Complement system 4 3 outcomes of complement activation stimulation of inflammation, opsonization and membrane attack complex classical, alternative, mannose-lectin pathways cell recognizes MHC1 on a healthy cell and does not kill it but on infected cell does not present MHC1 it kills it a series of proteins in the blood that complements other immune functions
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