Lab valuesOnline version Lab value matching game for lecture on Hematological System by Maura Davis 1 Platelet Count 2 Bleeding Time 3 Prothrombin Time 4 Partial Thromboplastin Time 5 Fibrinogen 6 Thrombin Time 7 Fibrin Split Products (FSPs) 150,000-400,000 Quality of circulating platelets decreased platelet production, aplastic anemia, leukemia, chemotherapy, bleeding, splenomegaly, platelet alloantibodies 4-5 minutes Ability of platelets to form platelet plug Presence of platelet inihibitors, uremia, hyperammonemia, Von Willebrand's disease 11-16 seconds Activation of factor VII in the extrinsic pathway Hepatic disease, vitamin K deficiency, malabsorption syndrome, antibiotic depletion of normal flora, bleeding loss of factor VII, coumadin derivatives 30-45 seconds Conversion of prothrombin time to thrombin Factor VIII deficiency, hepatic disease, presence of thrombin inhibitors, blood loss of coagulation factors 150-400mg/dl Quantity of circulating fibrinogen (not quality) Hepatic disease, uremia, bleeding, consumptive process of excess clot formation 10-15 seconds Conversion of thrombin and fibrinogen to fibrin Presence of thrombin inhibitor, abnormal fibrinogen <10mcg/mL or negative at 1:1000 dilution Determines amount of byproducts from lysed clots present in circulation; the d-dimer fragment can be measured to better determine whether the patient is experiencing DIC Hepatic failure, found approxiamately 2-3 days after large clot formation, excessive clotting disease (DIC)