Matching Pairs Med Genetic 3Online version FOREIGN by Anthony Flish 1 p2+2pq+q2 and p+q=1 2 Autosomal Recessiv Inheritance 3 Leber's Hereditary Optic Neuropathy, cause blindess, mitochondrial disease 4 X-linked Recessive 5 carrier frequency 6 Red-Green Color Blindess 7 Hemophilia A or B is X-Linked recessive Disorder. Which lacks? 8 X-linked Dominant Pedigree 9 Autosomal Codominant Inheritance 10 Sex Reversal Syndrome 11 Duchenne Muscular Dystrophy lacks Dystrophin which interact with actin as well as dystroglycan-sarcoglycan. stablizes sarcolemma 12 Autosomal Dominant inheritance 13 Y-linked 14 X-linked Recessive Pedigree 15 X-Linked Dominant inheritance 2pq No Father to Son transmission . Fragile X syndrome FMR1 protein. (CGG)-Arginine. Mutated gene for NADH Dehydrogenase. -Tend to skip generation -affected offspring born to unaffected parents. -equal frequency between both sex. affect both sex. appear in every generation. (CAN CAUSE NEW AUTOSOMAL DOMINANT MUTATION) increase intracellular Ca2+, activation depend on protease. Kinase level in blood (20x). Clumsy. Becker Muscular Dystrophy is less severe. lacks clotting factor VIII or IX. 2 alleles at locus produce 2 different phenotypes that appear in heterozygote (i.e. A,B,O blood group).. Emphysema (a1-antitrypsin) loss of SRY gene, gonad dysgenesis. Hardy Weinberg Equation lack light absorbing protein "Opsin"
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