Stages of Tissue HealingOnline version In this activity, you will try to match the clinical signs of tissue healing and characteristic tissue response to a specific stage of healing: acute, subacute, or chronic. by Evan Petersen 1 Acute Stage of Healing:Inflammation 2 Subacute Phase:Proliferation, Repair, and Healing 3 Chronic Stage: Maturation and Remodeling Vascular changes Exudation of cells and chemicals Clot formation Phagocytosis Neutralization of irritants Early fibroblastic activity Clinical Sign: Inflammation Clinical SIgn: Pain before tissue resistance Removal of noxious stimuli Growth of capillary beds into area Collagen formation Granulation tissue Very fragile, easily injured tissue Clinical Signs: Decreasing inflammation Clinical Sign: Pain synchronous with tissue resistance Maturation of connective tissue Contracture of scar tissue Remodeling of scar Collagen aligns to stress Clinical Signs: Absence of inflammation Clinical Sign: Pain after tissue resistance