Matching Pairs TBI TerminologyOnline version Watch the YouTube video "How Brain Damage Works" and then match the terms from the video to their definitions or descriptions. by Cindy Gibson 1 Primary injury 2 Calpain 3 Intracranial Pressure (ICP) 4 Glutamate 5 Ischemia 6 Edema 7 Apoptosis 8 Necrosis 9 Diffuse Axonal Injury 10 Coup-Contracoup Injury 11 Secondary Injury 12 Hemorrhage Cell death at sites of injury that spreads to surrounding neurons due to enzymes released by dying cells The brain strikes the inside of the skull in two opposing locations. Activated by calcium, this enzyme triggers breakdown of the cell's membrane Physical impact of the brain at the time of injury. Reduced blood flow Fluid accumulation Delayed brain pathologies that occur minutes to days after the initial brain impact. Bleeding due to ruptured blood vessel(s) cell suicide An excitatory neurotransmitter that triggers overexcitation in neurons when it leaks out of cells in large amounts. Swelling of the brain that causes it to push against the restraints of the skull Mechanical tearing and shearing of axons due to injury