Matching Pairs TBI TerminologyOnline version Watch the YouTube video "How Brain Damage Works" and then match the terms from the video to their definitions or descriptions. by Cindy Gibson 1 Ischemia 2 Calpain 3 Coup-Contracoup Injury 4 Necrosis 5 Glutamate 6 Intracranial Pressure (ICP) 7 Hemorrhage 8 Primary injury 9 Edema 10 Apoptosis 11 Diffuse Axonal Injury 12 Secondary Injury Activated by calcium, this enzyme triggers breakdown of the cell's membrane An excitatory neurotransmitter that triggers overexcitation in neurons when it leaks out of cells in large amounts. Fluid accumulation Physical impact of the brain at the time of injury. Mechanical tearing and shearing of axons due to injury cell suicide Swelling of the brain that causes it to push against the restraints of the skull The brain strikes the inside of the skull in two opposing locations. Delayed brain pathologies that occur minutes to days after the initial brain impact. Bleeding due to ruptured blood vessel(s) Cell death at sites of injury that spreads to surrounding neurons due to enzymes released by dying cells Reduced blood flow