Matching Pairs TBI TerminologyOnline version Watch the YouTube video "How Brain Damage Works" and then match the terms from the video to their definitions or descriptions. by Cindy Gibson 1 Calpain 2 Glutamate 3 Secondary Injury 4 Coup-Contracoup Injury 5 Intracranial Pressure (ICP) 6 Diffuse Axonal Injury 7 Edema 8 Apoptosis 9 Necrosis 10 Primary injury 11 Hemorrhage 12 Ischemia Fluid accumulation cell suicide Mechanical tearing and shearing of axons due to injury Swelling of the brain that causes it to push against the restraints of the skull An excitatory neurotransmitter that triggers overexcitation in neurons when it leaks out of cells in large amounts. Physical impact of the brain at the time of injury. Activated by calcium, this enzyme triggers breakdown of the cell's membrane The brain strikes the inside of the skull in two opposing locations. Bleeding due to ruptured blood vessel(s) Reduced blood flow Cell death at sites of injury that spreads to surrounding neurons due to enzymes released by dying cells Delayed brain pathologies that occur minutes to days after the initial brain impact.