Matching Pairs HIV Drug Mechanisms of ActionOnline version Match the HIV drug class with its mechanism of action by Ethan Lentz 1 Nucleoside reverse transcriptase inhibitors 2 HIV Protease inhibitors 3 Integrase inhibitors 4 Non-nucleoside reverse transcriptase inhibitors 5 CYP3A4 inhibitors (protease inhibitor boosters) Allosterically bind to reverse transcriptase to reduce molecular motion in the enzyme and inhibit its function Bind to the active site of HIV proteases preventing the creation of new viral particles Inhibit destruction of protease inhibitors by host metabolism Inhibits HIV integrase enzyme preventing insertion of viral cDNA into the host genome Acts as a substrate for reverse transcriptase, inserting into viral DNA and blocking replication at 3'-OH
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