Matching Pairs Bacteria+Antibiotics Matching Pairs GameOnline version Test your knowledge of bacteria with this fun matching pairs game! by Sophie A Overfield 1 Streptococcus pyogenes 2 Clostridium difficile 3 Vibrio cholerae 4 Campylobacter jejuni 5 Neisseria meningitidis 6 Pseudomonas aeruginosa 7 Helicobacter pylori 8 Klebsiella pneumoniae 9 Haemophilus influenzae 10 Streptococcus pneumoniae 11 Proteus mirabilis 12 Salmonella typhi 13 Legionella pneumophila 14 Mycobacterium tuberculosis 15 Listeria monocytogenes 16 Escherichia coli 17 Streptococcus viridans 18 Staphylococcus aureus Motile, non-spore-forming Catalase-negative, optochin-susceptible Spore-forming Optochin-resistant Catalase-negative Motile, urease-producing Grows on CCD Catalase-positive Facultative-anaerobe Fastidious Non-mucoid-producing, indole-positive Fastidious, intracellular, aerobic Ziehl-Neelson staining Non-lactose fermenting, facultative anaerobe Non-lactose fermenting, aerobic Uniflagellated, pili Mucoid-producing, indole-negative Flagellated, urease-producing 1 Given to mothers to prevent neonatal sepsis if positive for causative agent 2 Antibiotics used to treat meningitis of unknown causative agent 3 Listeria monocytogenes 4 Neisseria meningitidis 5 Use IV dexamethasone 6 Group B Streptococcus 7 Streptococcus viridans 8 Streptococcus pneumoniae Neurological sequelae of S. pneumoniae IM benzylpenicillin Most common cause of neonatal sepsis Susceptible to amoxicillin, not cephalosporins Make Local Health Authority aware, close contacts OD ciprofloxacin (few days rifampicin if allergic) Optochin-resistant Third generation cephalosporins e.g. ceftriaxone, cefotaxime Optochin-susceptible 1 Tetracyclines 2 Sulfonamides 3 Beta-lactams 4 Macrolides 5 Nitrofurans 6 Aminoglycosides 7 Glycopeptides 8 Quinolones 9 Fluoroquinolones Folic acid synthesis inhibitors Inhibits cell wall formation Bind to PBPs and inhibit cell wall formation/crosslinking (most action on Gram positive) Inhibit DNA synthesis Inhibits 50s subunit of ribosome Interfere with DNA, RNA and protein synthesis Inhibits 30s subunit of ribosome, doxycycline Inhibits 30s subunit of ribosome, streptomycin Inhibit DNA gyrase and topoisomerase IV 1 Beta-lactams 2 Tetracyclines 3 Monobactam 4 Macrolides 5 Glycopeptides 6 Aminoglycosides Penicillins, cephalosporins, carbapenems, monobactams Erythromycin, clarithromycin, azithromycin Doxycycline, lymecycline Gentamicin, tobramycin, streptomycin Vancomycin, teicoplanin Azetreonam 1 Vancomycin 2 Doxycycline / clarithromycin 3 Amoxicillin 4 Co-amoxiclav 5 Meropenems 6 Piperacillin + tazobactam 4 + extended-spectrum beta-lactamases 1 Streptococci, Listeria, Enterococci 5 + MRSA 3 + Pseudomonas 2 + Staphylococci, Haemophilus, E. coli 6 + atypical bacteria 1 Beta-lactams contra 2 Macrolides contra 3 Carbapenems contra 4 Macrolides caution 5 Rifampicin contra 6 Glycopeptides caution 7 Tetracyclines contra 8 Chloramphenicol contra 9 Aminoglycosides contra 10 Trimethoprim contra 11 Metronidazole contra 12 Sulfonamides contra 13 Fluoroquinolones caution Children <12yrs = deposition in bones and teeth. Renal impairment (-do) Jaundice Penicillin hypersensitivity, breast-feeding Myasthenia gravis G6PD deficiency, epilepsy, myasthenia gravis Porphyria Deafness, pregnancy, renal impairment Neonates <2wks = hypertrophic pyloric stenosis Pregnancy, breast-feeding Penicillin hypersensitivity Blood dyscrasias, pregnancy Alcohol = profuse vomiting Hepatic impairment 1 Fluoroquinolones AEs 2 Sulfonamides AEs 3 Glycopeptides AEs 4 Metronidazole AEs 5 Aminoglycosides AEs 6 Rifampicin AEs 7 Macrolides AEs 8 Trimethoprim AEs 9 Tetracyclines AEs 10 Chloramphenicol AEs Depression of haematopoiesis, hyperkalaemia Dyspepsia, rash, sleep disorders, pruritus Hyperkalaemia, rash Nephrotoxicity, ototoxicity, hypomagnesaemia Discolouration of saliva and urine, N+V, anorexia, haemolytic anaemia Stephens-Johnson Syndrome, rash, arrythmias Grey syndrome, blood disorders, optic neuritis Nephrotoxicity, ototoxicity, blood disorders (neutropenia) Dysphagia, oesophageal irritation, photosensitivity, headaches, visual disturbances Taste disturbance, anorexia
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