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Outline the in vitro coagulation cascades

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Outline the in vitro coagulation cascades

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intrinsic, extrinsic, and common pathways

Created by

Gawain
Gawain
United States

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Outline the in vitro coagulation cascades
 

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Outline the in vitro coagulation cascadesOnline version

intrinsic, extrinsic, and common pathways

by Gawain
1

XIa XIa vitro IXa X vivo XII Xa XIIa VIIIa XI aPTT XII IXa in Xa IX XIIa in

Intrinsic Pathway ( Contact Activation Pathway )
Triggered by exposure to negatively charged surfaces
Requires phospholipid from platelet membrane
Factors involved :
Factor ?
Activated by contact with foreign surfaces
activates Factor ?
activates Factor ?
+ cofactor ( activated by thrombin ) form tenase complex
Tenase complex activates Factor ?
activates common pathway
* Factor is not important ( real - life clotting ) , but it is critical ( lab tests like )

2

VIIa TF VII IXa Prothrombin Xa PT Xa X Time TF IX

Extrinsic Pathway ( Tissue Factor Pathway )
Triggered by tissue injury and exposure of tissue factor ( Factor III )
Phospholipid source = damaged endothelium ( tissue factor )
Factors involved :
Tissue Factor ( III ) binds with Factor ?
? VIIa complex activates Factor ?
? common pathway
? VIIa complex also activates Factor ?
Initiates coagulation quickly and bypasses the contact phase
Tested by ( )

3

Fibrinogen XIII Thrombin VIII V Prothrombin XIIIa Va Xa II IIa Fibrin Thrombin

Common Pathway
Starts with activation of Factor X ? Xa
Factors involved :
+ cofactor = Prothrombinase complex
Converts ( ) ? ( )
:
Converts ? monomers
Activates Factor ? ? crosslinks fibrin = stable clot
Activates Factors and ( positive feedback )

4

III XII II IX VIII factor VII XI X V tissue

State what factors belong to the intrinsic , extrinsic , and common pathways
Intrinsic / Contact System
Prekallikrein ( PK ) , high - molecular - weight kininogen ( HK ) , , , , and
Extrinsic
and ( )
Common pathway
, , , I

5

molecular XII weight BK high Prekallikrein kininogen PK HK Bradykinin BK

Describe contact activation and list the substances involved
Contact activation pathway : there is a substance in the blood initiating procoagulant molecules .
Activated by negatively charged surfaces ( i . e Endothelial cells , leukocytes , bacteria , thrombocytes )
( ) , - - ( ) , activated by negatively charged substances ? production of ( )
binds to cell membrane receptors ? starts signaling pathways ? increases inflammatory processes
Does not contribute to normal clot formation in vivo but does contribute to inflammation , blood pressure regulation and fibrinolysi s

 
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