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coagulation factors

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coagulation factors

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About this activity

List and describe the coagulation factors by roman numeral, common name designation, and major function(s)

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coagulation factors
 

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coagulation factorsOnline version

List and describe the coagulation factors by roman numeral, common name designation, and major function(s)

by Gawain
1

peptides Fibrinogen liver fibrin monomer

Factor I =
Made in
Cleaves into three parts :
two and 1
Fibrin monomers will polymerize via disulfide linkages
Technically considered a substrat e

2

plasma X accelerating liver

Factor V = factor
Labile factor ( degrades quickly , does not have good stability )
Made in
Considered a cofactor to factor

3

K V Xa VIII calcium XI anticoagulant Vitamin thrombin prothrombin Prothrombinase Xa Va liver C

Factor II =
Made in ? Dependent
Converts to via cleavage by Factor
complex ( Factor and ) is more efficient
Reaction requires
Activates Factor , , &
Acts as an by activating Protein
Enhances inflammation via chemotaxis & inc . expression cytoadhesion molecules
Aids in cellular proliferation via fibroblast activatio n

4

calciu VII tissue factor

Factor III =
Necessary cofactor to Factor

Factor IV =

5

used liver not K Stable thromboplastin proconvertin

Factor VI =

Factor VII =
factor
Made in
Activates tissue
Vitamin dependent facto r

6

Stuart antigen males liver liver coagulant area antihaemophilia Prower endothelium Labile activity dependen K vessel antibodies heterologous Vitamin X factor ristocetin cofactor recognized related Christmas factor liver

Factor VIII =
Produced by and .
factor ( degrades quickly , does not have good stability )
Transcribed from gene on Chromosome ( more common in )
Consists of four different portions
VIII ( VIII : c )
VIII ( VIII : Ag )
VIII ( VIII : RCo )
Antigen by ( vWF : AG )

Factor IX =
Made in

Factor X = - factor
Made in

7

fibrin contact calcium Hageman plasma factor thromboplastin antecedent stabilizing plasma polypeptide platelet stabilizing thrombin fibri fibrin XI covalent

Factor XI =
Activated by

Factor XII = factor
Contact factor
Stable protein
Works with other ? contact factors ? to activate Factor

Factor XIII = factor
Two forms
The generated factor is activated by
The factor is activated by a process requiring
Produces bonds between the chains of the

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