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Chapter 25 Cholinergic Drugs

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Chapter 25 Cholinergic Drugs

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Chapter 25 Cholinergic Drugs
 

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Chapter 25 Cholinergic DrugsOnline version

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by Breanna Spears
1

muscarinic nicotinic

There are two types of repetors in the parasympathetic nervous branch : receptors ( which stimulates smooth muscle ) and receptors ( which stimulates skeletal muscle ) .

2

acetylcholinesterase parasympathomimetic adrenergic Cholinergic synergistic

drugs mimic the activity of the parasympathetic nervous system . They are also called drug s

3

AChE ACh Acetylcholinesterase

( ) is an enzyme that can inactivate the neurotransmitter , thereby preventing the nerve synapse from continuing the nerve impulse .

4

acetylcholinesterse norepinephrine Acetylcholine ACh

( ) is the neurotransmission substance that carries nerve impulses across the parasympathetic branch of the autonomic nervous system .

5

colon lewy body dementia Alzheimer myasthenia gravis

This interruption in neurotransmission can diminish cognitive function , which is seen in illnesses such as disease .

6

anticolontise anticholinesterase acetylcholinsterase drugs cholinergic inhibitors dopamine

Drugs that inhibit the enzyme AChE are called or .

7

acting vision cardiac cholinergics digestion elimination respiratory circulatory reproductive direct

Drugs acting on the sympathetic nervous system more prominently impact the , , or systems . Cholinergic drugs that act on the parasympathetic nervous system more prominently impact , , and the system . Drugs like ACh are called - .

8

ACh muscle cholinergics anticholinesterase indirect stimulants AChe acting

Cholinergic drugs that prolong the activity of by inhibiting the release of are called - or . This occurs when there's a lack of ACh being released at the nerve endings of the PN S

9

myasthenia glaucoma immunotherapy gravis

An example of indirect action is the use of cholinergic drugs to treat , a disease that involves rapid fatigue of skeletal muscles . Primary treatment of this disease is accomplished with .

10

cholinergics urinary retention acting miosis neurogenic bladder micturition indirect-acting cholinergics direct

Drugs like ACh are called - . An example of cholinergic influence is on the act of ( voiding of urine ) .

11

cholinergic contraction fluid retention involuntary retention indirect-acting cholinergics parasympathetic direct urinary involuntary constricting retention volunty acting Urinary relaxing

Micturition is both a and an act . The branch of the autonomic nervous system party controls the ( ) process of micturition by the detrusor muscle and the bladder sphincter . results when micturition is impaired . Treatment of with - drugs causes of the bladder smooth muscles and passage of urine .

12

anticholinesterase muscle stimulant acting indirect direct-acting cholinergic micturition glaucoma mitosis cholinergic miosis

Treatment of with an - drugs produces ( constriction of the iris ) .

13

Norepinephrine Dopamine cholinergic Acytylcholinesterase Acetylcholine

Which of the following is the substance responsible for transmission of nerve impulses across the parasympathetic nervous system ?

14

Myasthenia abdominal cramping Urinary fluid retention gastroinintestinal issues relaxed gravis retention Cardiac arrythmias Neurogenic

Major uses of the cholinergic drugs are in the treatment of the following :
, bladder , and .

15

tissue perfusion Nausea myasthenia gravis diarrhea weakness cardiac flushing muscle urinary retention dizziness arrythmias respiratory distress salivation

General adverse reactions include the following :
, , abdominal cramping , , of the skin , , and .

16

iritis GI coronary atropine glaucoma peptic genitourinary corneal hypersensitivity asthma Bethanol hyperthyroidism

These drugs are contraindicated in clients with known to the drugs , , ulcers disease , artery disease , and . is contraindicated in those with mechanical obstruction of the or tracts . Clients with secondary , , abrasion , or any actue inflammatory disease of the eye should not use the ophthalamic cholinergic preparations .

17

hypotension cardiac C tachycardia E hypertension pregnancy coronary bradycardia arrhythmias D lactation megacolon

These drugs are used cautiously in clients with , epilepsy , , , recent occlusion , and . The safety of the drugs have NOT been established for use during ( pregnancy category ) , , or children

18

amplifies anticholinergic anticholinergic atropine acetylcholinesterase antagonizes synergistic eliminator agonizes Zyban cholinergic Bethanechol Pyridostigmine antidote

When drugs are administered with the other cholinergics , there is a ( the effect is greater than that of each of the two drugs separately ) effect of the drugs and greater risk for toxicity . Concurrent use of more than one drug the effects of cholinergic drugs . Because drugs can have this additive effect , is the drug used as an for overdose of cholinergic drugs .

19

Zyban atropine diarrhea salivation muscle nausea corticosteriods constipation weakness dry mouth Cholinergic

crisis ( cholinergic drug toxicity ) symptoms include severe abdominal cramping , , excessive , , rigidity and spasm , and clenching of the jaw . In case of drug overdose , an antidote such as is administered .

20

before response decreased client's presence absence gravis myasthenia increased between

For a client with , you have to assess the client for the or of the symptoms before each drug dose ( extreme fatigue , drooping eyelids , muscle weakness , inability to chew and swallow , etc ) . Carry out these assessments drug doses as well as immediately drug administered . Assessment is important because the dosage ferequently is or early in therapy , depending on the .

21

20-30 subcutaneous 30 30-60 buccal 90 oral 5 15 IV

Voiding usually occurs in - min after drug administration and - min after administration

22

gravis 2 myasthenia Sustained 4 release time-released 3-4 1-2

Oral drug administration is typically the route used to manage symptoms of . Clients with severe symptoms of the disease require the drug every - hr , even during the night . - tablets are available that alow less frequent dosing and help the client have longer undisturbed periods during the night .

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