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Desafío: Herencia Mitocondrial

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Desafío: Herencia Mitocondrial

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Afirmaciones sobre el mtDNA: ¿Verdadero o Falso?

Created by

Shadai Chávez López
Shadai Chávez López
Mexico

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Desafío: Herencia Mitocondrial
 

Desafío: Herencia MitocondrialOnline version

Afirmaciones sobre el mtDNA: ¿Verdadero o Falso?

by Shadai Chávez López
1

La frecuencia mutacional del mtDNA es menor que la del DNA nuclear.

2

MELAS, MERF, LOHN y Kearns-Sayre son ejemplo de enfermedades mitocondriales.

3

La forma del mtDNA es una cadena de doble hélice

4

Los principales aparatos y sistemas afectados en una enfermedad mitocondrial son: gastrointestinal, músculo-esquelético y respiratorio.

5

La homoplasmia se refiere a la presencia de diferentes tipos de mtDNA presentes en una célula

6

El genoma mitocondrial humano consta de 37 genes.

7

El mtDNA humano codifica 13 proteínas que forman parte de la cadena respiratoria.

8

La presentación de una enfermedad mitocondrial está relacionada con la heteroplasmia y homoplasmia.

9

El mtDNA se localiza en el núcleo junto al ADN nuclear.

10

Es posible encontrar de cientos a miles de copias de mtDNA dentro de una célula

11

La herencia mitocondrial puede mostrar heteroplasmia, con mtDNA de diferentes linajes en una misma célula.

12

El genoma mitocondrial humano contiene más de 1,000 genes.

13

En humanos, la herencia mitocondrial se transmite por la madre a todos sus hijos.

14

Las mutaciones en mtDNA se heredan exclusivamente a través de los hombres.

15

Al sospechar una enfermedad mitocondrial, el cariotipo es un estudio útil para iniciar el abordaje diagnóstico

 
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