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Actividad unidad 4

Created by

Maria Elena Martinez Roman
Maria Elena Martinez Roman
Mexico

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Actividad unidad 4

by Maria Elena Martinez Roman
1

La carcinogénesis es el proceso mediante el cual las células normales se transforman en células cancerosas, a través de alteraciones genéticas y epigenéticas.

2

Exposición a carcinógenos químicos, dietas pobres en antioxidantes y exceso de grasas saturadas pueden generar mutaciones y estrés oxidativo que promueven el cáncer.

3

Alteraciones como metilación del ADN, modificación de histonas y microARN anómalos pueden silenciar genes supresores de tumores o activar oncogenes sin cambiar la secuencia genética.

4

La inflamación persistente genera un entorno de citoquinas proinflamatorias y radicales libres que inducen daño celular continuo y estimulan la proliferación.

5

Los tumores inducen la formación de nuevos vasos sanguíneos para obtener oxígeno y nutrientes, facilitando el crecimiento y la metástasis, llamándose a este proceso angigenólisis.

6

La apoptosis elimina células dañadas o anormales; cuando este proceso se ve inhibido, las células defectuosas se limitan y pueden multiplicar la muerte celular.

7

Las tres etapas principales del proceso de carcinogénesis son iniciación, producción y propulsión.

8

La alteración de proteínas reguladoras como p53, p21 o ciclinas permite que las células dañadas sigan dividiéndose sin control.

9

El exceso de radicales libres daña el ADN, policarburos y membranas celulares, favoreciendo mutaciones y alteraciones en la señalización celular.

10

Las mutaciones activan oncogenes o inactivan genes supresores de tumores, provocando una división celular descontrolada.

 
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