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Crossword Puzzle
Crossword Puzzle

Sistema CRISPR-Cas9

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Sistema CRISPR-Cas9

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About this activity

CRISPR-Cas9 es una tecnología derivada de un sistema inmunitario adaptativo presente en procariotas (bacterias y arqueas).

Created by

Leandro Alvear
Leandro Alvear
Ecuador

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Sistema CRISPR-Cas9
 

Crossword Puzzle

Sistema CRISPR-Cas9Online version

CRISPR-Cas9 es una tecnología derivada de un sistema inmunitario adaptativo presente en procariotas (bacterias y arqueas).

by Leandro Alvear
1

Inactivación de un gen mediante errores generados durante la reparación del ADN tras el corte por Cas9.

2

Organismos procariotas en los que se descubrió originalmente el sistema CRISPR como mecanismo de defensa.

3

Versión inactivada de la Cas9 que se une al ADN sin cortarlo y se usa para regular la expresión génica.

4

Conjunto de modificaciones químicas que regulan la expresión génica sin alterar la secuencia del ADN.

5

Sistema de defensa adaptativo presente en bacterias y arqueas que reconoce y elimina ADN extraño; es la base de la tecnología de edición genética.

6

Mecanismo de reparación dirigido por homología que permite introducir cambios precisos en el ADN usando una plantilla donante.

7

Mecanismo de reparación del ADN propenso a errores que genera inserciones o deleciones, utilizado para inactivar genes (knockout).

8

Molécula que contiene la información genética de los organismos y que es modificada durante la edición genética con CRISPR-Cas9.

9

Secuencia corta de nucleótidos adyacente al ADN diana, indispensable para que la Cas9 reconozca y se una al sitio de corte.

10

ARN guía sintético que dirige a la proteína Cas9 hacia la secuencia exacta del ADN que se desea editar.

11

Proteína endonucleasa que actúa como “tijera molecular”, capaz de cortar ambas hebras del ADN en un sitio específico guiada por el ARN.

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