Immune Response Master Quiz

Froggy Jumps

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About this activity

Test your understanding of cell- and antibody-mediated immunity.

Created by

Quader Ahmed Jalili

India

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Immune Response Master Quiz


Froggy Jumps Immune Response Master QuizOnline version Test your understanding of cell- and antibody-mediated immunity. by Quader Ahmed Jalili 1 Which cells are the principal effectors of cell-mediated immunity (CMI)? a B cells b Neutrophils c Cytotoxic T lymphocytes (CTLs) 2 Which arm of immunity primarily combats intracellular pathogens? a Cell-mediated immunity b Innate immunity c Humoral immunity 3 Which cells are the major professional antigen-presenting cells (APCs)? a Dendritic cells, macrophages, and B cells b Fibroblasts c Eosinophils 4 What is the role of TH1 cells in immunity? a Promote antibody production via IL-4 b Promote cell-mediated responses via cytokines c Directly kill pathogens 5 Which pathway presents endogenous antigens to CD8 T cells? a Transcytosis pathway b Endocytic (exogenous) pathway c Cytosolic (endogenous) pathway 6 Which pathway presents exogenous antigens to TH cells? a Endocytic (exogenous) pathway b Transcytosis pathway c Cytosolic pathway 7 What is the main function of perforins in CTLs? a Form pores to deliver granzymes b Neutralize toxins c Block receptor signaling 8 Which molecule is essential for TH cell activation signals? a CD40-CD40L only b IL-2 receptor alone c CD28-B7 co-stimulation 9 Which cytokine drives CTL proliferation after activation? a IL-10 b IL-2 c IFN-α 10 What is ADCC primarily mediated by in immunity? a B cells b Macrophages c Natural killer (NK) cells 11 Which cells exhibit ADCC with antibody help? a Erythrocytes b NK cells and macrophages c Platelets 12 Which immunoglobulin class is first produced in a primary response? a IgM b IgA c IgG 13 Which feature is true about memory T cells? a Short-lived and slow to respond b Do not respond to antigens c Longer lifespan and rapid reactivation 14 What is the main role of NK cells? a Innate cytotoxic cells that kill stressed cells b Present antigens to T cells c Produce antibodies 15 What happens in germinal centers during B cell activation? a Somatic hypermutation and affinity maturation b Direct pathogen lysis c Immediate class switching only 16 Which antibody class is prevalent after class switching in follicles? a IgG (and others after switching) b IgE only c IgD only 17 What is the function of Fc receptors on phagocytes? a Direct antigen presentation b Cytotoxic signaling c Mediates opsonization and phagocytosis 18 Which cells can provide cytokines to direct B cell responses? a Activated TH cells b Red blood cells c Basophils 19 What is the hallmark of T cell receptor (TCR) signaling? a BCR signaling only b MHC-independent activation c TCR-CD3 complex activates downstream signaling 20 Which cells are described as ‘professional APCs’? a Erythrocytes b Neutrophils c Dendritic cells, macrophages, B cells 21 What is the main function of helper T cells (TH)? a Only secrete antibodies b Coordinate CMI and AMI via cytokines c Directly kill infected cells 22 Which pathway is associated with antigen cross-presentation to CD8 T cells? a Endocytic pathway only b Transcytosis pathway c Cytosolic pathway (endogenous antigens) 23 Which cells are involved in delayed-type hypersensitivity (DTH)? a B cells and neutrophils b Erythrocytes and platelets c Th1 cells and macrophages 24 What does class switching in B cells require? a Cytokine signals from TH cells b Only antigen binding c TCR signaling alone 25 Which event initiates signals for B cell activation? a NK cell contact b TCR engagement c BCR cross-linking by antigen 26 What is the role of follicular dendritic cells (FDCs)? a Present antigen to centrocytes in germinal centers b Present antigen to T cells in thymus c Directly kill pathogens 27 Which molecule on CTLs recognizes MHC I-peptide on targets? a CD4-MHC II interaction b TCR-CD3 complex with CD8 c BCR with IgM 28 Which cells release granzymes in CTL action? a B cells b Cytotoxic T cells c Basophils 29 Which condition is a primary consequence of ADCC? a Cytokine storm b Antibody neutralization only c Target cell lysis via perforin/granzymes 30 Which component is not a characteristic of NK cells? a Innate immunity b Cytotoxic activity c MHC restriction 31 In AMI, what is the outcome of complement activation? a Antigen presentation b Phagocytosis inhibition c Opsonization and membrane attack complex formation

Immune Response Master Quiz

Froggy Jumps

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Immune Response Master QuizOnline version

by Quader Ahmed Jalili

Which cells are the principal effectors of cell-mediated immunity (CMI)?

Which arm of immunity primarily combats intracellular pathogens?

Which cells are the major professional antigen-presenting cells (APCs)?

What is the role of TH1 cells in immunity?

Which pathway presents endogenous antigens to CD8 T cells?

Which pathway presents exogenous antigens to TH cells?

What is the main function of perforins in CTLs?

Which molecule is essential for TH cell activation signals?

Which cytokine drives CTL proliferation after activation?

What is ADCC primarily mediated by in immunity?

Which cells exhibit ADCC with antibody help?

Which immunoglobulin class is first produced in a primary response?

Which feature is true about memory T cells?

What is the main role of NK cells?

What happens in germinal centers during B cell activation?

Which antibody class is prevalent after class switching in follicles?

What is the function of Fc receptors on phagocytes?

Which cells can provide cytokines to direct B cell responses?

What is the hallmark of T cell receptor (TCR) signaling?

Which cells are described as ‘professional APCs’?

What is the main function of helper T cells (TH)?

Which pathway is associated with antigen cross-presentation to CD8 T cells?

Which cells are involved in delayed-type hypersensitivity (DTH)?

What does class switching in B cells require?

Which event initiates signals for B cell activation?

What is the role of follicular dendritic cells (FDCs)?

Which molecule on CTLs recognizes MHC I-peptide on targets?

Which cells release granzymes in CTL action?

Which condition is a primary consequence of ADCC?

Which component is not a characteristic of NK cells?

In AMI, what is the outcome of complement activation?