Autoimmunity Essentials Quiz

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Test key autoimmunity concepts.

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Quader Ahmed Jalili

India

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Autoimmunity Essentials Quiz


Froggy Jumps Autoimmunity Essentials QuizOnline version Test key autoimmunity concepts. by Quader Ahmed Jalili 1 What is immunological tolerance? a A state where the immune system ignores self-antigens b A vaccine-induced immunity c A state of constant immune activation 2 Central tolerance mainly deletes self-reactive cells in which tissue? a Spleen b Lymph nodes c Thymus for T cells and bone marrow for B cells 3 What is negative selection in T cell development? a Activation of all T cells b Deletion of self-reactive T cells c Activation of B cells 4 What is receptor editing in B cells? a Somatic hypermutation for higher affinity b Edited light-chain gene rearrangement to avoid self-reactivity c Class switching to IgA 5 Peripheral tolerance includes which mechanism? a Only central deletion b Anergy and regulatory T cells c Clonal selection and activation 6 What is anergy in T cells? a Unresponsiveness to antigen due to no co-stimulation b Immediate cell death c Hyperactivation of T cells 7 Sequestration of self-antigens contributes to which tolerance concept? a Central tolerance b Autoimmunity only c Peripheral tolerance 8 Molecular mimicry can lead to which outcome? a Vaccine failure b Autoimmune disease after infection c Immediate pathogen clearance 9 Epitope spreading describes what process? a Expansion of T cell recognition to self-epitopes b Antibody class switching c Direct B cell activation 10 Bystander activation involves which cells? a T regulatory cells only b Self-reactive TH1 cells activated nonspecifically c Only B cells activated 11 Which autoantibody is associated with Goodpasture syndrome? a Anti-TSH receptor b Anti-basement membrane antibodies (IgG to GBM) c Anti-dsDNA 12 Which test detects ANA for autoimmune diseases? a ELISA alone b Indirect immunofluorescence c Western blot 13 Anti-dsDNA antibodies are highly specific for which disease? a Rheumatoid arthritis b Hashimoto’s thyroiditis c Systemic lupus erythematosus (SLE) 14 Anti-Scl-70 antibodies are linked to which disease? a Sjögren’s syndrome b RA c Scleroderma 15 RA factor is an autoantibody targeting what part of IgG? a Light chain b Fab region c Fc portion 16 Anti-CCP antibodies are highly specific for which disease? a SLE b Sjögren’s c Rheumatoid arthritis 17 Lens antigens are an example of which antigen type? a Cross-reactive antigens b Neoantigens c Sequestered antigens 18 Which organ-specific autoimmune disease affects the thyroid commonly? a Sjögren’s syndrome b Hashimoto’s thyroiditis c Type 1 diabetes 19 Which syndrome shows linear IgG and C3b deposits on basement membranes? a Goodpasture syndrome b Hashimoto’s c SLE 20 Which test detects autoantibodies in autoimmune hemolytic anemia? a Coombs test b ELISA c Western blot 21 Which cell type mediates peripheral tolerance by cytokine secretion? a Regulatory T cells (Tregs) b B cells c Effector T cells 22 What is AICD in autoimmunity? a Autoantibody production b Antigen-induced clonal expansion c Activation-induced cell death 23 Which condition is linked to molecular mimicry after streptococcal infection? a Acute rheumatic fever b Myasthenia gravis c Type 1 diabetes 24 What is the hallmark of systemic autoimmune diseases? a Allergy symptoms only b Bacterial infection c Autoantibodies and self-reactive T cells 25 Which site is immunologically privileged, aiding tolerance? a Liver b Cornea c Skin 26 Which test is used to diagnose SLE? a PCR b Flow cytometry c Indirect immunofluorescence for ANA 27 What drives loss of Treg cell–mediated suppression? a Autoimmunity onset b Acute infection only c Enhanced tolerance 28 Which mechanism involves self-antigens escaping central tolerance? a Sequestration b Ignorance c Anergy 29 Which organ is primarily affected in Goodpasture syndrome? a Brain b Liver c Kidney and lung basement membranes 30 What antibody is used to screen for autoimmunity in SLE? a Antinuclear antibodies (ANA) b Anti-PR3 c Anti-MPO 31 What is an example of a systemic autoimmune disease? a Systemic lupus erythematosus b Graves’ disease only c Type 1 diabetes only 32 Which mechanism prevents self-reactivity via co-stimulation blockade? a Antibody production b B cell activation c Anergy via CTLA-4 engagement 33 Which autoimmune condition features anti-Ro/La antibodies? a Sjögren’s syndrome b RA c Hashimoto’s 34 Which process involves tissue damage releasing sequestered antigens? a Release of sequestered antigens b Central tolerance c Clonal deletion 35 Which autoimmune disease is marked by anti-dsDNA antibodies? a RA b SLE c Hashimoto’s 36 Which is a hallmark autoantibody in rheumatoid arthritis? a Anti-dsDNA b ANA c Anti-CCP

Autoimmunity Essentials Quiz

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Autoimmunity Essentials QuizOnline version

by Quader Ahmed Jalili

What is immunological tolerance?

Central tolerance mainly deletes self-reactive cells in which tissue?

What is negative selection in T cell development?

What is receptor editing in B cells?

Peripheral tolerance includes which mechanism?

What is anergy in T cells?

Sequestration of self-antigens contributes to which tolerance concept?

Molecular mimicry can lead to which outcome?

Epitope spreading describes what process?

Bystander activation involves which cells?

Which autoantibody is associated with Goodpasture syndrome?

Which test detects ANA for autoimmune diseases?

Anti-dsDNA antibodies are highly specific for which disease?

Anti-Scl-70 antibodies are linked to which disease?

RA factor is an autoantibody targeting what part of IgG?

Anti-CCP antibodies are highly specific for which disease?

Lens antigens are an example of which antigen type?

Which organ-specific autoimmune disease affects the thyroid commonly?

Which syndrome shows linear IgG and C3b deposits on basement membranes?

Which test detects autoantibodies in autoimmune hemolytic anemia?

Which cell type mediates peripheral tolerance by cytokine secretion?

What is AICD in autoimmunity?

Which condition is linked to molecular mimicry after streptococcal infection?

What is the hallmark of systemic autoimmune diseases?

Which site is immunologically privileged, aiding tolerance?

Which test is used to diagnose SLE?

What drives loss of Treg cell–mediated suppression?

Which mechanism involves self-antigens escaping central tolerance?

Which organ is primarily affected in Goodpasture syndrome?

What antibody is used to screen for autoimmunity in SLE?

What is an example of a systemic autoimmune disease?

Which mechanism prevents self-reactivity via co-stimulation blockade?

Which autoimmune condition features anti-Ro/La antibodies?

Which process involves tissue damage releasing sequestered antigens?

Which autoimmune disease is marked by anti-dsDNA antibodies?

Which is a hallmark autoantibody in rheumatoid arthritis?