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bio med and cml treatment

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bio med and cml treatment

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bio med and cml treatment

Created by

paankhuri bhatia
paankhuri bhatia
United Kingdom

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bio med and cml treatmentOnline version

bio med and cml treatment

by paankhuri bhatia
1

Chronic myeloid leukaemia ( CML ) is a myeloproliferative disorder caused by the , which results from formation of the - fusion gene . This gene encodes active , which causes uncontrolled proliferation of cells . The main treatment for CML is biological therapy in the form of ( TKIs ) . The first - line treatment is , a TKI that works by competitively inhibiting the - of the BCR - ABL tyrosine kinase , preventing of downstream signalling and abnormal cell growth . Imatinib is indicated as first - line therapy in , but it may be contraindicated or poorly tolerated in patients with significant , , or due to adverse effects such as or symptoms . In patients who develop or intolerance to Imatinib , second - generation TKIs such as Dasatinib and Nilotinib may be used . Dasatinib is a more TKI that inhibits BCR - ABL as well as SRC family kinases but it is contraindicated in patients at risk of or . Nilotinib is another second - generation TKI that selectively inhibits BCR - ABL tyrosine kinase and may be used as an alternative first - line agent or in Imatinib resistance , although it is contraindicated in patients with or significant disease . Bosutinib is an additional second - generation TKI used in later - line therapy for patients to multiple TKIs , and its use may be limited by and side effects . Ponatinib is a third - generation TKI specifically effective against the T315I mutation of BCR - ABL , which confers resistance to other TKIs , and is indicated in , but it is contraindicated in patients with high risk due to increased risk of . In situations where TKIs are unsuitable , such as , Interferon - ? may be used as a biological therapy , as it works by modulating the immune response and inhibiting myeloid proliferation , although it is less and associated with - like side effects and symptoms .

2

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3

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