HopHop HLA!

Froggy Jumps

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Mind Your Step

Created by

Salihah Yusof

Malaysia

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1	Salihah Yusof January 13, 2026	% 55	01:13
2	Alya Syafiqah June 17, 2026	% 31	00:50

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HopHop HLA!


Froggy Jumps HopHop HLA!Online version Mind Your Step by Salihah Yusof 1 What does HLA stand for? a Human Lymphatic Antigen b Human Lymphocyte Antigen c Human Leukocyte Antigen 2 Which cells mainly present HLA class I antigens? a B cells only b Professional APCs only c All nucleated cells 3 Which T cells interact with HLA class II molecules? a Gamma delta T cells b CD8+ cytotoxic T cells c CD4+ helper T cells 4 What is the primary role of HLA in transplantation? a Matching donor and recipient to reduce rejection b To identify viral antigens c To determine blood type 5 Which HLA molecule presents intracellular peptides to CD8+ T cells? a HLA class III b HLA class I c HLA class II 6 Which process describes how peptides are loaded onto MHC in cells? a Antibody crossing b Antigen processing and presentation c Complement activation 7 HLA polymorphism influences susceptibility to what? a Pathogens and disease outcomes b Blood type c Hair color 8 Which cells typically express HLA class II molecules? a Professional antigen-presenting cells b Red blood cells c All nucleated cells 9 In cancer, what role can HLA molecules play? a Direct tumor cell killing b Tumor antigen presentation to T cells c Antibody production 10 What is MHC restriction in T-cell responses? a T cells bind freely to any antigen b T cells recognize antigens only with specific MHC c MHC is not involved in recognition 11 A 24-year-old presents with fever, sore throat, lymphadenopathy. EBV infection is confirmed. Despite viral replication, infected cells persist. Which HLA-related mechanism best explains this? a Downregulation of HLA class I expression reduces recognition by CD8⁺ T cells b Increased expression of HLA class II on infected B cells enhances CD4⁺ T-cell activation c Polymorphism of HLA-DR molecules limits peptide binding of viral antigens 12 A cancer patient shows reduced HLA class I expression and increased HLA-G on tumor cells. Which mechanism best explains how the tumor escapes immune detection? a Inhibition of T-cell recognition by altered HLA expression b Increased antibody production against tumor cells c Enhanced complement-mediated lysis 13 A 50-year-old woman has symmetrical joint pain and morning stiffness lasting over one hour. Blood tests are positive for rheumatoid factor. Which HLA allele is most commonly associated with this disease? a HLA-B27 b HLA-A2 c HLA-DR4 14 A man undergoes a kidney transplant. Weeks later, he presents with a rise in serum creatinine. Renal biopsy shows endothelial damage and deposition of antibodies against donor HLA antigens. What is the most likely immunological mechanism involved? a Direct recognition of donor HLA by recipient T cells b Indirect presentation of donor HLA antigens by recipient APCs c Hyperacute rejection due to preformed anti-ABO antibodies 15 A 28-year-old woman undergoes a heart transplant. Three years later, she develops progressive shortness of breath and reduced ejection fraction. Biopsy shows fibrosis and vascular changes. Which mechanism best explains this finding? a Direct recognition of donor HLA by recipient T cells b Preformed anti-HLA antibodies causing hyperacute rejection c Indirect recognition leading to donor-specific antibody formation 16 A 24-year-old male has chronic low back pain and stiffness improving with exercise but worse at rest. Morning stiffness lasts over an hour, sacroiliac tenderness is present, and HLA-B27 is positive. What is the most likely diagnosis? a Rheumatoid arthritis b Ankylosing spondylitis c Psoriasis vulgaris

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HopHop HLA!

Froggy Jumps

About this activity

Created by

Download the paper version to play

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HopHop HLA!Online version

by Salihah Yusof

What does HLA stand for?

Which cells mainly present HLA class I antigens?

Which T cells interact with HLA class II molecules?

What is the primary role of HLA in transplantation?

Which HLA molecule presents intracellular peptides to CD8+ T cells?

Which process describes how peptides are loaded onto MHC in cells?

HLA polymorphism influences susceptibility to what?

Which cells typically express HLA class II molecules?

In cancer, what role can HLA molecules play?

What is MHC restriction in T-cell responses?

A 24-year-old presents with fever, sore throat, lymphadenopathy. EBV infection is confirmed. Despite viral replication, infected cells persist. Which HLA-related mechanism best explains this?

A cancer patient shows reduced HLA class I expression and increased HLA-G on tumor cells. Which mechanism best explains how the tumor escapes immune detection?

A 50-year-old woman has symmetrical joint pain and morning stiffness lasting over one hour. Blood tests are positive for rheumatoid factor. Which HLA allele is most commonly associated with this disease?

A man undergoes a kidney transplant. Weeks later, he presents with a rise in serum creatinine. Renal biopsy shows endothelial damage and deposition of antibodies against donor HLA antigens. What is the most likely immunological mechanism involved?

A 28-year-old woman undergoes a heart transplant. Three years later, she develops progressive shortness of breath and reduced ejection fraction. Biopsy shows fibrosis and vascular changes. Which mechanism best explains this finding?

A 24-year-old male has chronic low back pain and stiffness improving with exercise but worse at rest. Morning stiffness lasts over an hour, sacroiliac tenderness is present, and HLA-B27 is positive. What is the most likely diagnosis?