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Inflammation and Joint Pain

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Inflammation and Joint Pain

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Inflammation and Joint Pain

Created by

Joy
Joy
United Kingdom

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Inflammation and Joint Pain
 

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Inflammation and Joint PainOnline version

Inflammation and Joint Pain

by Joy
1

Inflammation is a fundamental biological response characterised by cardinal signs such as , , , , and . In arthritis , inflammation is a primary driver of joint pain and tissue damage , involving , , and . Various forms of arthritis , including osteoarthritis , rheumatoid arthritis , , pseudogout , and , manifest joint pain and inflammation through distinct etiologies and pathophysiological mechanism s

2

Joint pain in arthritis is largely driven by , where inflammatory mediators lower the pain threshold of joint , leading to ( pain from non - noxious stimuli ) and ( exaggerated pain response to noxious stimuli ) .

The inflammatory process involves the following three phases :

: Detection of harmful stimuli triggers immune cells ( e . g . , mast cells , ) to release signalling molecules like , , and

: Vasodilation and increased vascular permeability lead to increased blood flow and leakage of into the injured area , forming

: Immune cells , primarily neutrophils , migrate from the bloodstream to the , where they are activated and or

3

Rheumatoid arthritis is a musculoskeletal disease . It features severe inflammation due to an imbalance of - and - cytokines , leading to persistent inflammation , , and . RA commonly presents with , bilateral and symmetrical of small joints , particularly the and joints , and systemic symptoms like and

4

is characterised by ( high uric acid in the blood ) and the deposition of within , leading to acute inflammatory arthritis . It typically presents as a painful , red , hot , swollen joint , often affecting the big toe's joint ( ) . , which are deposits of crystals in soft tissues , can develop in chronic gout . Risk factors include , sex ( more common in ) , hypertension , obesity , use , , and diets high in purines or .

5

Pseudogout ( ( ) ) is caused by the deposition of crystals in articular cartilage , leading to acute inflammation . It is a common cause of in the elderly , often involving the , but can also affect , , and joints . Symptoms include severe pain , , swelling , erythema , tenderness , and sometimes feve r

6

is a destructive arthropathy caused by an intra - articular infection , often by microorganisms via or spread . with abundant blood supply ( e . g . , shoulder , hip , knee ) are commonly affected . It requires prompt treatment due to the risk of and . Clinical presentation includes fever , , and a hot , swollen , acutely painful joint with movement . is the most commonly identified pathogen in childre n

 
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