Immunology: Defects, Transplants & Tumors

Froggy Jumps

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Quiz on immunity basics.

Created by

Dr. Gurjeet Singh

India

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Froggy Jumps Immunology: Defects, Transplants & TumorsOnline version Quiz on immunity basics. by Dr. Gurjeet Singh 1 Which immune defect characterizes severe combined immunodeficiency (SCID)? a Absent T and B cell function b Isolated B cell deficiency c Overactive NK cells 2 Hyperacute transplant rejection is primarily driven by which mechanism? a Preexisting antibodies in the recipient b Delayed T cell activation c Depleted T cells post-transplant 3 Chediak-Higashi syndrome affects which immune process? a Antigen presentation by DCs b Phagocyte microtubule function c Complement synthesis 4 Which variable reduces graft rejection risk most in transplantation? a Younger donor age b Higher immunosuppressant dose c Mismatched HLA antigens 5 Tumor cells often evade immunity by downregulating what? a IL-2 receptor b MHC class I expression c PD-1 on T cells 6 Primary antibody deficiencies mainly affect which arm of immunity? a Humoral (antibody) immunity b Cell-mediated immunity c Complement-only defense 7 Which therapy enhances anti-tumor immunity by checkpoint blockade? a PD-1/PD-L1 inhibitors b BTK inhibitors c TNF inhibitors 8 X‑linked agammaglobulinemia results from a defect in what? a CD3 complex mutation b BTK gene hindering B cell maturation c RAG1/2 gene deficiency 9 Graft-versus-host disease is mainly a risk in which scenario? a Solid organ transplant b Allogeneic stem cell transplantation c Autologous transplant 10 Which cytokine is pivotal for cytotoxic T cell responses against tumors? a TGF-β b IFN-γ c IL-4

Froggy Jumps

Immunology: Defects, Transplants & TumorsOnline version

Quiz on immunity basics.

by Dr. Gurjeet Singh

Which immune defect characterizes severe combined immunodeficiency (SCID)?

Absent T and B cell function

Isolated B cell deficiency

Overactive NK cells

Hyperacute transplant rejection is primarily driven by which mechanism?

Preexisting antibodies in the recipient

Delayed T cell activation

Depleted T cells post-transplant

Chediak-Higashi syndrome affects which immune process?

Antigen presentation by DCs

Phagocyte microtubule function

Complement synthesis

Which variable reduces graft rejection risk most in transplantation?

Younger donor age

Higher immunosuppressant dose

Mismatched HLA antigens

Tumor cells often evade immunity by downregulating what?

IL-2 receptor

MHC class I expression

PD-1 on T cells

Primary antibody deficiencies mainly affect which arm of immunity?

Humoral (antibody) immunity

Cell-mediated immunity

Complement-only defense

Which therapy enhances anti-tumor immunity by checkpoint blockade?

PD-1/PD-L1 inhibitors

BTK inhibitors

TNF inhibitors

X‑linked agammaglobulinemia results from a defect in what?

CD3 complex mutation

BTK gene hindering B cell maturation

RAG1/2 gene deficiency

Graft-versus-host disease is mainly a risk in which scenario?

Solid organ transplant

Allogeneic stem cell transplantation

Autologous transplant

Which cytokine is pivotal for cytotoxic T cell responses against tumors?

TGF-β

IFN-γ

IL-4

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Immunology: Defects, Transplants & Tumors

Froggy Jumps

About this activity

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Download the paper version to play

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Immunology: Defects, Transplants & TumorsOnline version

by Dr. Gurjeet Singh

Which immune defect characterizes severe combined immunodeficiency (SCID)?

Hyperacute transplant rejection is primarily driven by which mechanism?

Chediak-Higashi syndrome affects which immune process?

Which variable reduces graft rejection risk most in transplantation?

Tumor cells often evade immunity by downregulating what?

Primary antibody deficiencies mainly affect which arm of immunity?

Which therapy enhances anti-tumor immunity by checkpoint blockade?

X‑linked agammaglobulinemia results from a defect in what?

Graft-versus-host disease is mainly a risk in which scenario?

Which cytokine is pivotal for cytotoxic T cell responses against tumors?

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