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C difficile

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C difficile

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Created by

Jessica
Jessica
United Kingdom

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C difficile
 

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C difficileOnline version

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by Jessica
1

Healthy intestinal epithelial cells are initially intact .
C . difficile germinate into toxin - producing vegetative cells in the colon .
24 hours after exposure : cells of the colon lining appear normal .
30 hours after exposure : Toxin A ( ) and Toxin B ( ) start damaging epithelial cells , causing and fluid .
36 hours after exposure : inflamed cells and die , leading to as spores exit the colon . influx occurs , forming a on the colon surface .

2

Both toxins Rho - family GTPases , disrupting the cytoskeleton .
is less potent than , which is 100 ? 1000 times more potent .
TcdA mainly acts as an , causing fluid and inflammation .
TcdB acts as a , directly damaging cells .
TcdA binds structures on gut epithelial cells , while TcdB binds receptors and has a cell tropism .
requires cholesterol to form pores in cells , whereas is less cholesterol - dependent .

3

Binary toxin ( ) severity , recurrence , hospital stay , and mortality ; it acts of TcdA and TcdB .
protects against phagocytosis .
Flagella aid and adherence .
enzymes help penetrate the mucus layer .
Adhesins and facilitate to epithelial cells .

 
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