Heme Synthesis & Porphyria Quiz

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Heme pathway and porphyrias

Created by

Dr.Jefferson

India

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Froggy Jumps Heme Synthesis & Porphyria QuizOnline version Heme pathway and porphyrias by Dr.Jefferson 1 What is the rate-limiting enzyme in heme synthesis? a ALA synthase (delta-ALA synthase) b Ferrochelatase c ALA dehydratase (PBG synthase) 2 Where does the first step of heme synthesis take place? a Mitochondria b Nucleus c Cytosol 3 Acute intermittent porphyria mainly causes excess of which intermediate? a Protoporphyrin IX b Heme c Porphobilinogen 4 Porphyrias often present with symptoms in which body system? a Digestive tract b Nervous system c Muscular system 5 Which cofactor is important for ALA synthase activity? a Pyridoxal phosphate (B6) b Folate c Biotin 6 Diagnosis of porphyria often involves elevated levels of what in urine? a Urobilinogen b Porphobilinogen (PBG) c Heme 7 Which enzyme converts ALA to porphobilinogen? a ALA synthase b Ferrochelatase c ALA dehydratase (porphobilinogen synthase) 8 Ferrochelatase deficiency leads to which clinical feature? a Abdominal pain only b Neuropathy without skin signs c Photosensitivity with protoporphyrin IX accumulation 9 Which steps of heme synthesis occur in mitochondria? a All steps b First and last steps c Middle steps only 10 Porphyria symptoms can be triggered by what factors? a Certain drugs and fasting b Hyperhydration c High-protein diet

Froggy Jumps

Heme Synthesis & Porphyria QuizOnline version

Heme pathway and porphyrias

by Dr.Jefferson

What is the rate-limiting enzyme in heme synthesis?

ALA synthase (delta-ALA synthase)

Ferrochelatase

ALA dehydratase (PBG synthase)

Where does the first step of heme synthesis take place?

Mitochondria

Nucleus

Cytosol

Acute intermittent porphyria mainly causes excess of which intermediate?

Protoporphyrin IX

Heme

Porphobilinogen

Porphyrias often present with symptoms in which body system?

Digestive tract

Nervous system

Muscular system

Which cofactor is important for ALA synthase activity?

Pyridoxal phosphate (B6)

Folate

Biotin

Diagnosis of porphyria often involves elevated levels of what in urine?

Urobilinogen

Porphobilinogen (PBG)

Heme

Which enzyme converts ALA to porphobilinogen?

ALA synthase

Ferrochelatase

ALA dehydratase (porphobilinogen synthase)

Ferrochelatase deficiency leads to which clinical feature?

Abdominal pain only

Neuropathy without skin signs

Photosensitivity with protoporphyrin IX accumulation

Which steps of heme synthesis occur in mitochondria?

All steps

First and last steps

Middle steps only

Porphyria symptoms can be triggered by what factors?

Certain drugs and fasting

Hyperhydration

High-protein diet

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Heme Synthesis & Porphyria Quiz

Froggy Jumps

About this activity

Created by

Download the paper version to play

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Heme Synthesis & Porphyria QuizOnline version

by Dr.Jefferson

What is the rate-limiting enzyme in heme synthesis?

Where does the first step of heme synthesis take place?

Acute intermittent porphyria mainly causes excess of which intermediate?

Porphyrias often present with symptoms in which body system?

Which cofactor is important for ALA synthase activity?

Diagnosis of porphyria often involves elevated levels of what in urine?

Which enzyme converts ALA to porphobilinogen?

Ferrochelatase deficiency leads to which clinical feature?

Which steps of heme synthesis occur in mitochondria?

Porphyria symptoms can be triggered by what factors?

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