DM Drug Mechanisms Quiz

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MOA, effects, interactions of DM meds.

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Ansley Schwing

United States

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DM Drug Mechanisms Quiz


Froggy Jumps DM Drug Mechanisms QuizOnline version MOA, effects, interactions of DM meds. by Ansley Schwing 1 What is the primary MOA of insulin in diabetes management? a Replaces or supplements endogenous insulin b Inhibits insulin receptors c Stimulates glucagon release 2 Common adverse effect of most insulins? a Hypoglycemia b Hyperkalemia c Hypertension 3 One key contraindication for many insulins? a Hyperthyroidism b Asthma c Heart failure 4 Which medication class slows gastric emptying and suppresses glucagon? a Pramlintide (amylin analog) b Dapagliflozin c Metformin 5 Pramlintide is added to insulin therapy to:** a Slow gastric emptying and suppress glucagon b Increase glucagon secretion c Increase gastric motility 6 GLP-1 receptor agonists primarily address which glucose component? a Fasting glucose b Post-prandial glucose c Glucose-independent glucose 7 Name a GLP-1 agonist used for type 2 DM. a Empagliflozin b Metformin c Liraglutide 8 Another GLP-1 agonist used in practice? a Semaglutide b Acarbose c Glimepiride 9 DPP-4 inhibitors MOA? a Inhibits hepatic glucose output b Slows inactivation of incretins (GLP-1, GIP) c Stimulates beta-cell apoptosis 10 Name a DPP-4 inhibitor. a Sitagliptin b Pioglitazone c Repaglinide 11 SGLT2 inhibitors MOA? a Inhibit intestinal glucose absorption b Inhibit renal glucose reabsorption c Stimulate pancreatic insulin release 12 Common adverse effect of SGLT2 inhibitors? a Hypothyroidism b Genital fungal infections c Weight gain 13 An important contraindication for SGLT2 inhibitors? a CrCl < 15 mL/min b Asthma c Hyperthyroidism 14 Name an SGLT2 inhibitor. a Nateglinide b Acarbose c Empagliflozin 15 Metformin MOA? a Stimulate insulin secretion b Increase insulin sensitivity and decrease hepatic gluconeogenesis c Increase glucose absorption 16 Metformin major adverse effect that requires monitoring? a Hypertension b GI effects and lactic acidosis risk c Hyperkalemia 17 Metformin contraindication? a Renal impairment (CrCl <30 mL/min) b Hypoglycemia c Hyperlipidemia 18 TZDs (pioglitazone/rosiglitazone) MOA? a Inhibit hepatic glucose production b Increase insulin sensitivity via PPAR-gamma c Block K+ channels in beta cells 19 TZD notable adverse effect? a Weight gain and edema b Hypokalemia c Hyperglycemia 20 TZD contraindication? a Asthma b Heart failure c Renal stones 21 Which drug class adds on to improve postprandial glucose and has ASCVD benefits? a SGLT2 inhibitors b Alpha-glucosidase inhibitors c DPP-4 inhibitors 22 Meglitinides MOA? a Inhibit glucose absorption b Glucose-dependent insulin secretagogues c Increase glucagon 23 Name a meglitinide. a Rosiglitazone b Repaglinide c Acarbose 24 Nateglinide timing in meals? a Given with each meal b Given only with insulin c Given once daily at night 25 Alpha-glucosidase inhibitors MOA? a Decrease intestinal starch breakdown b Stimulate insulin release c Increase gastric emptying 26 Name an AGI example. a Acarbose b Empagliflozin c Liraglutide 27 Dopamine agonist used as add-on in type 2 DM? a Metformin b Bromocriptine c Sitagliptin 28 Bromocriptine’s known adverse effect category? a Hyperkalemia b N/V, somnolence, hypotension c Hyperglycemia 29 What drug class has ASCVD and CKD renal benefits? a SGLT2 inhibitors (empagliflozin, canagliflozin) b Sulfonylureas c Alpha-glucosidase inhibitors 30 Insulin dosing concept shown in the table? a Only at night b Only with ketoacidosis c Before meals or around meals 31 Inhaled insulin brand listed? a Humalog b Afrezza c Lantus 32 Short-acting insulin analogue example? a Detemir (Levemir) b NPH (Humulin) c Lispro (Humalog) 33 Long-acting basal insulin example? a Glargine (Lantus) b Regular insulin c Aspart (Novolog) 34 Combination insulin products are used to? a Treat lipids b Replace glucose intake c Cover meals and basal needs 35 Which drug class is second-line for type 2 DM with variable renal considerations? a DPP-4 inhibitors b AGIs c Glinides 36 Which class is a first line for type 2 DM often with postprandial focus? a Sulfonylureas b GLP-1 receptor agonists c TZDs 37 What is a key adverse for GLP-1 agonists besides GI? a Hypoglycemia (rare) b Pancreatitis risk c Hyperkalemia 38 Which drug class may cause thyroid cancer signal with liraglutide? a GLP-1 receptor agonists b DPP-4 inhibitors c SGLT2 inhibitors 39 Which drug class may cause angioedema risk? a TZDs b Metformin c DPP-4 inhibitors 40 Rationale for caution with metformin and contrast media? a Risk of lactic acidosis b Hypokalemia c Hyperglycemia 41 Insulin therapy requires what safety precaution? a Avoid carbs entirely b Seal with air-tight cap c Carry candy or snack for hypoglycemia 42 Pramlintide dosing note? a Taken only with breakfast b Only at night c 0.5% cost and postprandial focus 43 Sulfonylureas MOA? a Stimulate insulin secretion by closing K+ channel b Decrease hepatic glucose output c Delay gastric emptying 44 Which drug can interact with warfarin and is a DPP-4 inhibitor? a Linagliptin b Metformin c Liraglutide 45 Which DM drug class is known for potential skin reactions and dyscrasias? a Sulfonylureas (glyburide, glipizide) b GLP-1 agonists c SGLT2 inhibitors 46 What metabolic effect do SGLT2 inhibitors have that aids CKD? a Increase GI absorption b Slow renal decline and renal protection c Increase hepatic gluconeogenesis 47 Which medication is listed as first line for type 1 and GDM in the table? a Insulin b Dapagliflozin c Metformin 48 What adverse effect is common to most insulin regimens? a Hyperglycemia b Hypoglycemia c Hyperkalemia 49 Which class slows glucagon secretion and reduces appetite? a Nateglinide b Pramlintide (amylin agonist) c Acarbose 50 Which drug class includes sitagliptin and alogliptin? a GLP-1 receptor agonists b Meglitinides c DPP-4 inhibitors 51 Which insulin is given by inhalation? a Lantus b Afrezza c Humalog 52 Which class is contraindicated in severe renal impairment? a Exenatide b Glipizide c Metformin 53 Which agent has a potential association with pancreatitis? a GLP-1 receptor agonists b Insulin c Metformin 54 What is a notable interaction concern with metformin? a Radiographic contrast media b Beta-blockers c ACE inhibitors 55 Name a rapid-acting insulin analog. a Aspart (NovoLog) b NPH c Glargine 56 Name a fixed 70/30 insulin combo. a Novolog 70/30 b Humulin 70/30 c Lantus 70/30 57 Which class can cause bladder or prostate cancer signals? a SGLT2 inhibitors b DPP-4 inhibitors c TZDs (pioglitazone/rosiglitazone) 58 Which DM drug class is often used with insulin for type 1 or GDM? a Amylin analog (pramlintide) b Biguanides c DPP-4 inhibitors 59 Which drug has ASCVD benefits and weight loss with once-weekly options? a Me glitinides b Sulfonylureas c GLP-1 receptor agonists 60 Which DM drug class requires renal dosing considerations? a Alpha-glucosidase inhibitors b TZDs c DPP-4 inhibitors 61 Which class acts as secretagogues via beta-cell stimulation? a GLP-1 agonists b DPP-4 inhibitors c Sulfonylureas 62 Which insulin type has the longest duration listed? a Glargine (Lantus) b Lispro c Regular insulin 63 Which drug is linked to lactic acidosis risk? a Acarbose b Metformin c Pramlintide 64 Which drug class can cause hypoglycemia especially with SU or insulin? a TZDs b SGLT2 inhibitors c DPP-4 inhibitors 65 Which class includes bromocriptine as an add-on? a DPP-4 inhibitors b GLP-1 agonists c Dopamine agonist 66 Which medication is used as a second line for type 2 DM focused on post-meal glucose? a Metformin b Acarbose (AGI) c Empagliflozin 67 Which agent is recommended to be taken 15 minutes before meals? a Detemir b NPH c Insulin lispro/aspart (rapid-acting analogs) 68 What is a key adverse of GLP-1 agonists besides GI? a Hypoglycemia b Hyperkalemia c Pancreatitis risk 69 Which class can cause angioedema as a side effect? a TZDs b SGLT2 inhibitors c DPP-4 inhibitors 70 Which drug class may improve ASCVD benefits and support weight loss? a Meglitinides b AGIs c GLP-1 receptor agonists 71 Which drug should be used with caution in hepatic failure? a DPP-4 inhibitors b TZDs c Metformin 72 What is the primary goal of insulin therapy in T1DM? a Prevent hyperglycemia and DKA b Increase hepatic glucose output c Increase glucagon 73 Which drug is a rapid-acting insulin analog? a Regular insulin b Aspart (Novolog) c NPH

DM Drug Mechanisms Quiz

Froggy Jumps

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DM Drug Mechanisms QuizOnline version

by Ansley Schwing

What is the primary MOA of insulin in diabetes management?

Common adverse effect of most insulins?

One key contraindication for many insulins?

Which medication class slows gastric emptying and suppresses glucagon?

Pramlintide is added to insulin therapy to:**

GLP-1 receptor agonists primarily address which glucose component?

Name a GLP-1 agonist used for type 2 DM.

Another GLP-1 agonist used in practice?

DPP-4 inhibitors MOA?

Name a DPP-4 inhibitor.

SGLT2 inhibitors MOA?

Common adverse effect of SGLT2 inhibitors?

An important contraindication for SGLT2 inhibitors?

Name an SGLT2 inhibitor.

Metformin MOA?

Metformin major adverse effect that requires monitoring?

Metformin contraindication?

TZDs (pioglitazone/rosiglitazone) MOA?

TZD notable adverse effect?

TZD contraindication?

Which drug class adds on to improve postprandial glucose and has ASCVD benefits?

Meglitinides MOA?

Name a meglitinide.

Nateglinide timing in meals?

Alpha-glucosidase inhibitors MOA?

Name an AGI example.

Dopamine agonist used as add-on in type 2 DM?

Bromocriptine’s known adverse effect category?

What drug class has ASCVD and CKD renal benefits?

Insulin dosing concept shown in the table?

Inhaled insulin brand listed?

Short-acting insulin analogue example?

Long-acting basal insulin example?

Combination insulin products are used to?

Which drug class is second-line for type 2 DM with variable renal considerations?

Which class is a first line for type 2 DM often with postprandial focus?

What is a key adverse for GLP-1 agonists besides GI?

Which drug class may cause thyroid cancer signal with liraglutide?

Which drug class may cause angioedema risk?

Rationale for caution with metformin and contrast media?

Insulin therapy requires what safety precaution?

Pramlintide dosing note?

Sulfonylureas MOA?

Which drug can interact with warfarin and is a DPP-4 inhibitor?

Which DM drug class is known for potential skin reactions and dyscrasias?

What metabolic effect do SGLT2 inhibitors have that aids CKD?

Which medication is listed as first line for type 1 and GDM in the table?

What adverse effect is common to most insulin regimens?

Which class slows glucagon secretion and reduces appetite?

Which drug class includes sitagliptin and alogliptin?

Which insulin is given by inhalation?

Which class is contraindicated in severe renal impairment?

Which agent has a potential association with pancreatitis?

What is a notable interaction concern with metformin?

Name a rapid-acting insulin analog.

Name a fixed 70/30 insulin combo.

Which class can cause bladder or prostate cancer signals?

Which DM drug class is often used with insulin for type 1 or GDM?

Which drug has ASCVD benefits and weight loss with once-weekly options?

Which DM drug class requires renal dosing considerations?

Which class acts as secretagogues via beta-cell stimulation?