Matching Pairs pathophysiologyOnline version inflammation, tissue repair, wound healing by angelina 1 inflammation reaction 2 dolor 3 rubor 4 functio laesa 5 calor 6 tissue repair & wound healing 7 immune response 8 tumor regeneration & replacement innate & adaptive swelling heat redness pain vascular & cellular response loss of function 1 cytokines source 2 histamine source 3 prostaglandins source 4 leukotrienes action 5 complement proteins source 6 leukotrienes source 7 prostagliandins action 8 complement protein action 9 cytokines action 10 histamine action recruit leukocytes, bronchoconstriction coordinate immune response, promote inflamation leukocytes, mast cells pain, fever, vasodialation macrophages, t cells liver, plamsa proteins mast cells, basophils attract immune cells, destrroy pathogens damaged tissues, leukocytes vasodialation & increased vascular permeability 1 hemorrhagic exudates 2 serosanguineous 3 adaptive 4 assessing wound exudate 5 purulent or suppuratice exudate 6 serous exudate 7 innate immunity Contain pus; composed of degraded white blood cells, proteins, and tissue debris Specific, learned response involving lymphocytes and memory. clear/ pale yellow Result from plasma entering the inflammatory site bright red watery damage to blood vessels or when there is significant leakage of red cells from the capillaries light pink 1.color 2. amount 3. smell 4. culture/swab if any of the above are abnormal Nonspecific, immediate defense (e.g., neutrophils, macrophages, barriers). 1 labile body cells 2 granulomatous inflammation define 3 acute inflamation ex 4 healing secondary 5 Chronic inflamation define 6 acute inflammation define 7 permanant body cells 8 healing primary 9 stable body cells 10 chronic inflammation ex 11 granulomatous inflammation ex splinter, tuberculosis great loss of tissue with contamination, wounds heal from the bottom up. Cannot undergo mitotic division Ex. neurons and cardiac cells Normally stop dividing when growth ceases but can regenerate if injured. Ex. hepatocytes (liver cells), lymphocytes (a type of white blood cell) relatively short duration; nonspecific early response to injury Aimed primarily at removing the injurious agent and limiting tissue damage a distinctive form of chronic inflammation characterized by the formation of granulomas — small, organized collections of macrophages Continue to divide and replicate throughout life, replacing cells that are continually being destroyed. Ex. skin cells, GI intestinal lining A recurrent or progressive acute inflammatory process or a low-grade smoldering response that fails to evoke an acute response small, clean wound with appoximated edges copd flu 1 inflammatory phase 2 maturational phase 3 proliferative phase 1 year The final phase, focused on strengthening and remodeling of the repaired tissue. 4-24 days Focuses on tissue regeneration and building new structures Focuses on tissue regeneration and building new structures fibroblast 1-6 days Goals to stop bleeding, remove debris and prepare for healing via platelet aggregation and vasodilation 1 Graft Versus Host Disease 2 Rheumatoid arthritis 3 type1 hypersensitivity 4 transplant rejection acute 5 transplant rejection chronic 6 graves disease 7 type 2 hypersensitivity 8 type 1 diabetes 9 Transplant Rejection hyperacute 10 type 3 hypersensitivity 11 SLE "lupus" 12 type 4 hypersensitivity 13 Immunodeficiency Disorders secondary 14 Immunodeficiency Disorders primary •Skin: rash, peeling •Liver: jaundice, elevated LFTs •GI: diarrhea, abdominal pain •Recurrent infections •Severe infections from common organisms •Failure to thrive (in infants) fatigue, joint pain, butterfly rash tachycardia, heat intolerance, weight loss polyuria, polydipsia, weight loss •Hemolysis (jaundice, pallor, fatigue) •Fever/chills during transfusion reaction •Newborn hemolytic disease (Rh incompatibility) •Joint pain •Rash •Proteinuria/kidney involvement •Vasculitis •Features of SLE (fatigue, butterfly rash) •Progressive organ failure •Hypertension (kidney) •Shortness of breath (lung) •Itching, urticaria (hives) •Rhinorrhea, sneezing (hay fever) •Bronchoconstriction, wheezing (asthma) •Hypotension, airway swelling (anaphylaxis) •Frequent infections •Opportunistic infections (Pneumocystis, Candida) •Weight loss •Fever, night sweats •Low CD4 count joint swelling, morning stiffness •Organ turns mottled, cyanotic •Immediate graft failure •Redness, itching, blistering (contact dermatitis) •Induration at TB skin test site •Fever •Organ dysfunction (e.g., rising creatinine in kidney transplant)
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