Frontotemporal disease

Froggy Jumps

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Frontotemporal disease

Created by

Ashok Kannan

United States

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2	DK March 25, 2026	% 100	00:46
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Froggy Jumps Frontotemporal diseaseOnline version Frontotemporal disease by Ashok Kannan 1 Which of these primary progressive aphasias has an effortful, halting speech? a Nonfluent variant primary progressive aphasia b Semantic variant primary progressive aphasia c Logopenic variant primary progressive aphasia 2 Which of these primary progressive aphasias is associated with Alzheimer disease pathology, rather then frontotemporal disease? a Nonfluent variant primary progressive aphasia b Semantic variant primary progressive aphasia c Logopenic variant primary progressive aphasia 3 What percent of FTD has a clear inheritance pattern (autosomal dominant inheritance)? a 10-25% b 30-45% c 40-55% 4 Which of the following is NOT one of the pathologies associated with a frontotemporal disease (behavioral variant or PPA)? a TDP43 b beta-amyloid c alpha-synuclein 5 Of the multiple biomarkers being studied, which one is the furthest along (closest to being used in the real world)? a HDGFL2 b Nfl c CSF acTau 6 What is one of the issues with Nfl as a biomarker? a Hard to get accurate numbers b It can indicate multiple diseases, not just FTD c It can't differentiate between psychiatric disorders and FTD 7 What is Nfl best at discriminating between? a FTD and psychiatric disorders b FTD and other tau disorders c bvFTD and primary progressive aphasias (PPAs) 8 What is the differential diagnosis for bvFTD (what other things can it be)? a Lewy body disease, psychiatric disorders, Alzheimer disease b primary progressive aphasias, psychiatric disorders, Alzheimer disease c Lewy body disease, primary progressive aphasias, Alzheimer disease

Froggy Jumps

Frontotemporal diseaseOnline version

Frontotemporal disease

by Ashok Kannan

Which of these primary progressive aphasias has an effortful, halting speech?

Nonfluent variant primary progressive aphasia

Semantic variant primary progressive aphasia

Logopenic variant primary progressive aphasia

Which of these primary progressive aphasias is associated with Alzheimer disease pathology, rather then frontotemporal disease?

Nonfluent variant primary progressive aphasia

Semantic variant primary progressive aphasia

Logopenic variant primary progressive aphasia

What percent of FTD has a clear inheritance pattern (autosomal dominant inheritance)?

10-25%

30-45%

40-55%

Which of the following is NOT one of the pathologies associated with a frontotemporal disease (behavioral variant or PPA)?

TDP43

beta-amyloid

alpha-synuclein

Of the multiple biomarkers being studied, which one is the furthest along (closest to being used in the real world)?

HDGFL2

Nfl

CSF acTau

What is one of the issues with Nfl as a biomarker?

Hard to get accurate numbers

It can indicate multiple diseases, not just FTD

It can't differentiate between psychiatric disorders and FTD

What is Nfl best at discriminating between?

FTD and psychiatric disorders

FTD and other tau disorders

bvFTD and primary progressive aphasias (PPAs)

What is the differential diagnosis for bvFTD (what other things can it be)?

Lewy body disease, psychiatric disorders, Alzheimer disease

primary progressive aphasias, psychiatric disorders, Alzheimer disease

Lewy body disease, primary progressive aphasias, Alzheimer disease

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Frontotemporal disease

Froggy Jumps

About this activity

Created by

Download the paper version to play

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Frontotemporal diseaseOnline version

by Ashok Kannan

Which of these primary progressive aphasias has an effortful, halting speech?

Which of these primary progressive aphasias is associated with Alzheimer disease pathology, rather then frontotemporal disease?

What percent of FTD has a clear inheritance pattern (autosomal dominant inheritance)?

Which of the following is NOT one of the pathologies associated with a frontotemporal disease (behavioral variant or PPA)?

Of the multiple biomarkers being studied, which one is the furthest along (closest to being used in the real world)?

What is one of the issues with Nfl as a biomarker?

What is Nfl best at discriminating between?

What is the differential diagnosis for bvFTD (what other things can it be)?

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