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The Immune System Story

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The Immune System Story

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Students will walk through terms related to the immune system and how it is triggered and operates.

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The Immune System Story
 

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The Immune System StoryOnline version

Students will walk through terms related to the immune system and how it is triggered and operates.

by Kyla Cymone
1

James was hiking through the forest when he scraped his knee on a sharp rock . Almost instantly , his body ? s activated to fight off any harmful invaders . His skin and mucous membranes served as , while enzymes like in his tears helped break down bacterial cell walls . All mammalian cells have - ( ) that bind to molecules found on pathogen cell walls , allowing them to correctly identify friend from foe . Soon , redness and swelling appeared at the wound site due to the a process that increases blood flow and allows immune cells to reach the injured area .

At the injury site , , the most abundant white blood cells , arrived first and began engulfing bacteria through , a process in which cells ingest harmful microbes . Meanwhile , , a type of white blood cell that resides in tissues , released , a chemical that triggered more inflammation . As the immune response continued , another type of white blood cell , targeted larger parasitic invaders , while , large phagocytic cells , arrived to clean up debris and dead pathogens .

Throughout the body , ( ) circulate and detect abnormal membrane proteins and release chemicals that cause , a programmed cell death or suicide . If James were to encounter a viral infection upon scraping his knee , are chemicals that infected cells release that trigger healthy , nearby cells to respond by secreting substances that prevent infected cells from replicating . This series of events also triggers the , made up of around 30 proteins found in the blood that leads to the lysis ( bursting ) of invading cells .

2

As the infection persisted , James ? s , a specialized network of cells and proteins , began a more targeted attack . His , a type of white blood cell , recognized specific invaders and helped mount a defense . These cells are made up of specialized T cells , and B cells .

The response began when a captured fragments of the invading pathogen ( called an , or name tag , usually containing pathogenic proteins ) and displayed them on its surface to alert other immune cells . Only one specific part of the name tag is used to bind to antigen receptors that trigger an immune response ; this part is known as an .

3

are adaptive immune cells that produce , proteins that specifically bind to and neutralize pathogens . B cells bind to epitopes floating in body fluids or attached to pathogens , while only bind to fragments presented by the host cell on their own membrane .

The special protein complex that holds the antigen fragment ( epitope ) on the host cell's plasma membrane is called the . read these molecules and trigger different responses based off of the type of T cell they are .

Helper are regulatory immune cells that release , signaling proteins , that activate other cells for the adaptive immune response and acts as a to prevent overreaction of adaptive response . specialize in recognizing and killing infected cells via apoptosis and memory . allows the immune system to respond faster if exposed to pathogen again .

All mature in an organ called the , found in the chest of babies . Initially , James ? s immune system was experiencing a , the initial immune response to a pathogen . If he encountered the same pathogen again , his would generate a , a faster and stronger reaction . B cells are related to the , which uses antibodies and phagocytosis to attack pathogens , while cytotoxic T cells specifically are related to the - , which triggers the destruction of infected cells .

4

Not all immunity is developed through infection . James had received a as a child , which exposed him to harmless forms of pathogens and triggered providing long - term protection . His younger sister , however , received antibodies from their mother ? s milk , an example of , which provided temporary protection from another individual .

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