Drug design startegies & Chiral switch

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Essentials of chiral switches and examples

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Ashraf

Egypt

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Froggy Jumps Drug design startegies & Chiral switchOnline version Essentials of chiral switches and examples by Ashraf 1 What does the term chiral switching describe in drug development? a Combining two enantiomers into a single racemate b Developing single enantiomers from racemate drugs. c Producing racemic mixtures from single enantiomers 2 Which disaster prompted stricter FDA rules on enantiomer identification? a Thalidomide disaster b Vioxx disaster c Tamiflu disaster 3 In thalidomide, which enantiomer is responsible for teratogenic effects? a S-isomer b R-isomer c Both enantiomers equally 4 What is a main merit of chiral switching? a Lowers potency b Increases racemate complexity c Enhanced efficacy and safety profile 5 Which drug pair exemplifies a chiral switch from racemate to single enantiomer? a Ofloxacin to Levofloxacin b Omeprazole to Esomeprazole c Citalopram to Escitalopram 6 Esomeprazole is the S-enantiomer of which drug? a Omeprazole b Pantoprazole c Lansoprazole 7 Eszopiclone is the marketed single enantiomer of which racemate? a Clonazepam b Diazepam c Zopiclone 8 Which drug is an example of a chiral switch with improved pharmacokinetics and safety? a Ciprofloxacin b Ranitidine c Escitalopram 9 Levocetirizine is the (R)-enantiomer of which antihistamine? a Loratadine b Cetirizine c Diphenhydramine 10 FDA 1987 NDA guidelines require what regarding chirality? a Identify all chiral centers and isomers b Require racemate submission only c Ignore enantiomeric composition

Froggy Jumps

Drug design startegies & Chiral switchOnline version

Essentials of chiral switches and examples

by Ashraf

What does the term chiral switching describe in drug development?

Combining two enantiomers into a single racemate

Developing single enantiomers from racemate drugs.

Producing racemic mixtures from single enantiomers

Which disaster prompted stricter FDA rules on enantiomer identification?

Thalidomide disaster

Vioxx disaster

Tamiflu disaster

In thalidomide, which enantiomer is responsible for teratogenic effects?

S-isomer

R-isomer

Both enantiomers equally

What is a main merit of chiral switching?

Lowers potency

Increases racemate complexity

Enhanced efficacy and safety profile

Which drug pair exemplifies a chiral switch from racemate to single enantiomer?

Ofloxacin to Levofloxacin

Omeprazole to Esomeprazole

Citalopram to Escitalopram

Esomeprazole is the S-enantiomer of which drug?

Omeprazole

Pantoprazole

Lansoprazole

Eszopiclone is the marketed single enantiomer of which racemate?

Clonazepam

Diazepam

Zopiclone

Which drug is an example of a chiral switch with improved pharmacokinetics and safety?

Ciprofloxacin

Ranitidine

Escitalopram

Levocetirizine is the (R)-enantiomer of which antihistamine?

Loratadine

Cetirizine

Diphenhydramine

FDA 1987 NDA guidelines require what regarding chirality?

Identify all chiral centers and isomers

Require racemate submission only

Ignore enantiomeric composition

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Drug design startegies & Chiral switch

Froggy Jumps

About this activity

Created by

Download the paper version to play

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Drug design startegies & Chiral switchOnline version

by Ashraf

What does the term chiral switching describe in drug development?

Which disaster prompted stricter FDA rules on enantiomer identification?

In thalidomide, which enantiomer is responsible for teratogenic effects?

What is a main merit of chiral switching?

Which drug pair exemplifies a chiral switch from racemate to single enantiomer?

Esomeprazole is the S-enantiomer of which drug?

Eszopiclone is the marketed single enantiomer of which racemate?

Which drug is an example of a chiral switch with improved pharmacokinetics and safety?

Levocetirizine is the (R)-enantiomer of which antihistamine?

FDA 1987 NDA guidelines require what regarding chirality?

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