Apalutamide: Dosing and Adverse Effects Quiz

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Dosing and AEs overview

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Extend Pharmacy

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Apalutamide: Dosing and Adverse Effects Quiz


Froggy Jumps Apalutamide: Dosing and Adverse Effects QuizOnline version Dosing and AEs overview by Extend Pharmacy 1 What is the standard daily oral dose of apalutamide for adults? a 180 mg daily b 240 mg daily c 120 mg daily 2 If a patient’s dose level is -1, what is the daily dose? a 240 mg/day b 180 mg/day c 120 mg/day 3 What should be done for intolerable or Grade 3 toxicity? a Hold until recovery to Grade 1/baseline, then resume at same or lower dose b Increase dose to counteract toxicity c Discontinue permanently 4 What action is taken if seizures occur on therapy? a Reduce dose by one level b Continue with same dose c Discontinue palatably 5 Which enzyme interaction can raise apalutamide levels (strong inhibitor example)? a CYP2C8 inhibitors (e.g., gemfibrozil) b CYP1A2 inhibitors (e.g., caffeine) c CYP2C9 inhibitors (e.g., warfarin) 6 What is the approximate half-life of apalutamide? a About 1 day b About 3 days c About 6 hours 7 Can 60 mg tablets be dispersed in applesauce for those who have trouble swallowing? a Yes, per guidance in the monograph b Only with crushing and mixing c No, tablets must be swallowed whole 8 Baseline monitoring recommended for apalutamide includes which of the following? a Baseline MRI of brain only b Baseline TSH and ECG, PSA and disease progression c Baseline chest X-ray only 9 In hepatic impairment, how is dosing adjusted at baseline for mild/moderate disease? a No adjustment required b Dose reduced by 50% c Dose increased by 25% 10 What is the reported incidence of hypertension with apalutamide? a About 25% (14% severe) b About 40% c Less than 5%

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Apalutamide: Dosing and Adverse Effects Quiz

Froggy Jumps

About this activity

Created by

Download the paper version to play

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Apalutamide: Dosing and Adverse Effects QuizOnline version

by Extend Pharmacy

What is the standard daily oral dose of apalutamide for adults?

If a patient’s dose level is -1, what is the daily dose?

What should be done for intolerable or Grade 3 toxicity?

What action is taken if seizures occur on therapy?

Which enzyme interaction can raise apalutamide levels (strong inhibitor example)?

What is the approximate half-life of apalutamide?

Can 60 mg tablets be dispersed in applesauce for those who have trouble swallowing?

Baseline monitoring recommended for apalutamide includes which of the following?

In hepatic impairment, how is dosing adjusted at baseline for mild/moderate disease?

What is the reported incidence of hypertension with apalutamide?