Isabelle's Totally Awesome (and educational) Game

Froggy Jumps

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About this activity

I promise!

Created by

Isabelle Whetsel

United States

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1	test2 April 19, 2026	% 91	00:45
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Froggy Jumps Isabelle's Totally Awesome (and educational) GameOnline version I promise! by Isabelle Whetsel 1 What is an RdRP? a RNA-Dependent RNA Polymerase b Reduced-Dependency of RNA Polymerase c RNA-Dependent DNA Polymerase 2 What does RdRP do? a (+) RNA → (-) RNA b (+) RNA → DNA c (-) RNA → DNA 3 What is the problem with the previous Machine Learning Approaches a Idk, they were just bad b Only looked at sequence similarity, missed highly divergent RdRPs c Only looked at structural similarity, missed highly divergent RdRPs 4 What type of machine learning did they use for LucaProt? a Convoluted Neural Network (CNNs) b Recurrent Neural Networks (RNNs) c Transformer-Based Architecture 5 What does a transformer-based architecture do? a Iterative query for the sequence for comparison to RdRPs b Compares with the entirety of NCBI's Blast Database to RdRPs c Uses structural and sequence data to compare for similarity to RdRPs 6 What is the ICTV a International Committee on Taxonomy of Viruses b Intentional Craziness of reality TeleVision c Impeccable Committee on Taxonomy of Viruses 7 What does putative mean? a I don't know Isabelle, why are you asking me? b Likely / Probable c Punitive / Punishing 8 What was notable about Nido? a Fun guy with a fun name from a fun place b They found the largest RNA virus – 47.3kb c They found the largest RNA virus ~2,132 nt 9 How did they train LucaProt? a aA mix of other things and DNAPol sequences b Random Metagenomic RNA from around the world c RNAPol, Reverse Transcriptases + DNAPol 10 What do you think they should have based the LucaProt acronym on? a Last Common Ancestor Protein b Losers Underclassify Compared to our Analysis of Proteins c Linkage of Unicellular Classification of Analyzed Proteins 11 What is your favorite (made up) acronym a ADULTING: Another Day Understanding Life’s Tedious, Irritating, Never-ending Grown-up Stuff b BUSY: Being Under Stress Year-round c NAPS: Necessary Afternoon Power Siesta

Froggy Jumps

Isabelle's Totally Awesome (and educational) GameOnline version

I promise!

by Isabelle Whetsel

What is an RdRP?

RNA-Dependent RNA Polymerase

Reduced-Dependency of RNA Polymerase

RNA-Dependent DNA Polymerase

What does RdRP do?

(+) RNA → (-) RNA

(+) RNA → DNA

(-) RNA → DNA

What is the problem with the previous Machine Learning Approaches

Idk, they were just *bad*

Only looked at sequence similarity, missed highly divergent RdRPs

Only looked at structural similarity, missed highly divergent RdRPs

What type of machine learning did they use for LucaProt?

Convoluted Neural Network (CNNs)

Recurrent Neural Networks (RNNs)

Transformer-Based Architecture

What does a transformer-based architecture do?

Iterative query for the sequence for comparison to RdRPs

Compares with the entirety of NCBI's Blast Database to RdRPs

Uses structural and sequence data to compare for similarity to RdRPs

What is the ICTV

International Committee on Taxonomy of Viruses

Intentional Craziness of reality TeleVision

Impeccable Committee on Taxonomy of Viruses

What does putative mean?

I don't know Isabelle, why are you asking me?

Likely / Probable

Punitive / Punishing

What was notable about Nido?

Fun guy with a fun name from a fun place

They found the largest RNA virus – 47.3kb

They found the largest RNA virus ~2,132 nt

How did they train LucaProt?

aA mix of other things and DNAPol sequences

Random Metagenomic RNA from around the world

RNAPol, Reverse Transcriptases + DNAPol

What do you think they should have based the LucaProt acronym on?

Last Common Ancestor Protein

Losers Underclassify Compared to our Analysis of Proteins

Linkage of Unicellular Classification of Analyzed Proteins

What is your favorite (made up) acronym

ADULTING: Another Day Understanding Life’s Tedious, Irritating, Never-ending Grown-up Stuff

BUSY: Being Under Stress Year-round

NAPS: Necessary Afternoon Power Siesta

You can integrate the game into an LMS compatible with LTI 1.1 or LTI 1.3 such as Canvas, Moodle, or Blackboard. This way, the scores will be automatically saved into the platform’s gradebook.

Isabelle's Totally Awesome (and educational) Game

Froggy Jumps

About this activity

Created by

Download the paper version to play

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Froggy Jumps

Isabelle's Totally Awesome (and educational) GameOnline version

by Isabelle Whetsel

What is an RdRP?

What does RdRP do?

What is the problem with the previous Machine Learning Approaches

What type of machine learning did they use for LucaProt?

What does a transformer-based architecture do?

What is the ICTV

What does putative mean?

What was notable about Nido?

How did they train LucaProt?

What do you think they should have based the LucaProt acronym on?

What is your favorite (made up) acronym

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