Matching Pairs Compounding weeks 1-13Online version GANG U NEED TO DO GOOD IN THEORY OR ELSE YOU WILL FAIL by Audree Dulnuan 1 Octagon border 2 What is HPA regulates? 3 Extreme danger 4 WHMIS 5 What does GHS (WHMIS 2015) do? 6 HPR 7 Danger 8 Caution 9 What are key elements of WHMIS 10 When did WHMIS came into effect 11 CPR 12 HPA 13 GHS (WHMIS 2015) 14 Upside down triangle border Globally harmonized system Hazardous products regulations Hazard classification, cautionary labelling of containers, provision of MSDSs, worker education programs Means the products may cause temporary or permanent injury or death. Defines & classifies the hazards through labels & safety data sheets. Means the injury will most likely be temporary, but death may occur w extreme exposure Means that the container itself is dangerous Workplace Hazardous Materials Information System Means exposure w even small amounts of the product may cause temporary or permanent injury or death. Means that the contents of the container are dangerous Hazardous Products Act October 31, 1988 (The first whmis) Set labelling & MSDS requirements for suppliers. Controlled product regulations 1 2 3 4 5 6 7 8 9 10 Corrosion Flame over circle (oxidizing) Exploding bomb (explosive) Flame (flammable) Hazards to the environment Exclamation mark (health hazards) Biohazardous infectious materials Health hazard Gas cylinder (gass under pressure) Skull & crossbones (acute toxicity) 1 Humectant 2 Hariy areas 3 Stratum corneum 4 Palms & soles 5 Dry, scaly skin conditions 6 Emollient 7 Oleaginous 8 Cracks & sores 9 Wet/oozy skin conditions 10 Cream 11 Ointment 12 Gel 13 Mucosal surfaces 14 Lotion 15 Occlusive 16 Skin folds 17 Inflamed skin Bland preparations; avoid alcohol & acidic preparations. ointments & oils are appropriate Wet compresses & soaks followed by creams/ointments Lotion, solution, gel or foam Substance that promotes retention of water in the skin by forming a barrier that prevents moisture in the skin Agent which softens the skin or soothes irritation on skin Usually considered thicker than a solution & more likely to contain oil as well as water or alcohol Bricks & mortar allow substances to pass Aqueous or alcoholic monophasic semisolid emulsion Semi-solid, water-free (80% oil), 6 months exp. rich in, covered w, producing oil, oily/greasy Use a cream or a lotion Ointment or cream may be preffered creams, lotions, & drying pastes Substance that causes water retention Non-irritating formulations to avoid irritating eroded surfaces Thicker than a lotion 70% water & 30% grease, a 50/50 emulsion of oil & water (30 days exp.) 1 Regulated Pharmacy personel 2 Compounding Record-CR 3 What levigating agent is used for cream? 4 What does centennial college use as an alternative w MFR/CR 5 Pharmacy manager/pharmacy department head 6 Non-regulated personnel 7 Non-sterile compounding supervisor 8 What levigating agent is used for ointment? 9 MFR-Master Formulation Records MFS-Master formula sheet Glycerin Mineral oil Patient-specific preparation, lot, exp, weights, names, quality control Responsible & accountable for compounding & patient care Recipe, list of instructions, ingredient list/preparation instructions Oversees the entire pharmacy Can only perform assigned compounding tasks under supervision after proper training Specifically manages & supervises compounding activities 1 Level C 2 Simple 3 Methylparaben & propylparaben 4 Group 2 5 Level B 6 Moderate 7 Risk assessment 8 Tween 20 & Tween 80 9 Group 1 10 Level A 11 NIOSH 12 Complex 13 Group 3 Non-antineoplastic drugs, meets one or more NIOSH hazardous drugs anti-fungal preservative Non-antineoplastic drugs, pose reproductive risk Requires special calculations/procedures National Institute for Occupational Safety & Health Preparing using USP monograph-specified ingredients, procedures, equipment, stability/BUD and following manufacturer directions separate space when compounding simple & complex. Emulsifying agents Dedicated room, complex preparations, or small quantities need more training w no interruptions. Requires special training, environment, facilities, equipment. Dedicated room & negative pressure, C-PEC Must be reviewed every 12 months. Antineoplastic drugs (cytotoxic drugs) 1 Syrups 2 Compounding Techniques for Oral Elixirs 3 Menthol, crystals 4 Density formula 5 Urea 6 Mixing liquids techniques 7 Suspension 8 Relative density is exactly 1 9 Relative density less than 1 10 Specific gravity 11 Aromatic waters 12 Solutions 13 Eutectic Mixture 14 Specific gravity formula 15 Menthol & camphor 16 Elixirs 17 Relative density greater than 1 18 Density Quantity of mass & volume, absolute term, P Density of substance/density of water Ratio of a substance's weight to the weight of same volume of water Solutions that are sweetened & alcohol-based (5%-40%) The density is the same as water A mixture of 2 or more components that do not mix together forms into a liquid. g/ml mass/volume The substance would sink Clear saturated aqueous solutions of volitile oils or aromatic substances Use to improve the taste some foul or bitter tasting active ingredients Needs to be dissolved in alcohol, anti-pruritic Anti-pruritic, eutectic mixture Substance would float Higher density liquid should be added to lower density liquids while constantly stirring. Liquids that contain ingredients, both active & inert, not soluble in the vehicle Water component is added to the alcohol component Clear liquid preparations Dissolved in boiling water, emollient agent 1 Why is 70% most effective? 2 99% Alcohol 3 Methylcellulose 4 Sodium benzoate 5 OTC prodcuts that contains alcohol 6 Lower concentration of alcohol 7 Sucrose 8 Alcohol in 12yrs & up 9 Chlorhexidine 10 Alcohol in 6yrs-12yrs old Suspending agent, used to thicken liquid to prevent it from settling to the bottom quickly Common sugar, added to medicines as a sweetening agent Less than 6yrs old should be alcohol-free. Max alcohol 5% anti-fungal, added to oral liquids to prevent fungal growth Antiseptic, vehicle, diluent 10 % max alcohol Antiseptic, effective against gram-negative/positive bacteria, yeast, fungi 50% of alcohol and lower may be less effective & requires more time 60%-90% alcohol is effective 1 Midazolam Syrup (Benzodiazepine) 2 Methadone labelling 3 What is the appropirate measuring device for Methadone 4 PPE-2 pairs of chemotherapy gloves 5 PPE mask N95 6 Methadone 7 True discrepancies (shortage/loss) 8 Features of C-SEC 9 Maintenance of C-PEC 10 Waste management 11 Auxillary label for methadone 12 Tetracycline 13 C-PEC 14 Effects of methadone 15 C-SEC 16 Methadone for pain 17 Take Home doses Measured using devices of 0.1 mL increments, only drugs authorized for drug addiction, effective 80% It's important to filter after preparation; it may cause a fever. Keep in refrigerator & May be fatal to child or adult Relieve anxiety & produce sleepiness before surgery, produce amnesia, treats status epilepticus patient signs: doses will be kept locked, will not lend/sell, will take doses properly, return empty bottles, have regular urine tests. Product name, total dose, drug has been diluted, drink the entire contents of bottle, date of ingestion Pharmaceutical products that are expired or no longer usable are considered pharmaceutical waste. Spills should complete an event report. Should be changed 3.5 hours of continuous work after each removal, if contamination has occurred. Containment secondary engineering control, the room which C-PEC is placed for compounding Level C Dispensette: 0.5-5 mL, 0.5% accurate Containment primary engineering control. Ventilated device to minimize exposure of workers & the environment Long-acting opioids act slower in the body; effects may last 24-36 hrs a day, can take weeks. when deactivating/decontaminating C-PEC, spills, cleaning 12 air changes per hour, negative pressure -2.5 Pa, no windows Should be inspected every 6 months; all reusable equipment should be deactivated & cleaned. Equipment should not be removed. Must be reported externally to Health Canada within 10 days Only MD can prescribe, for use in non-cancer pain, 6-8 hrs of pain relief
Match the description to the correct Amendment from the Bill of Rights.