Diabetes Mellitus: Pathogenesis Quiz

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Pathogenesis of diabetes

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Jayaseelan

India

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Diabetes Mellitus: Pathogenesis Quiz


Froggy Jumps Diabetes Mellitus: Pathogenesis QuizOnline version Pathogenesis of diabetes by Jayaseelan 1 What is the primary defect in type 2 diabetes pathogenesis? a Insulin resistance with progressive beta-cell dysfunction b Primary insulin overproduction causing hypoglycemia c Autoimmune beta-cell destruction 2 In type 1 diabetes, what mainly drives beta-cell loss? a Chronic insulin excess causing receptor downregulation b B-cell antibody-mediated destruction c T-cell mediated autoimmunity against beta cells 3 What is lipotoxicity in diabetes pathogenesis? a Chronic lipid overload damages beta cells and worsens function b Low fat intake triggering hypersensitivity c Excess insulin causing fat storage 4 What is glucotoxicity? a Chronic hyperglycemia impairs beta-cell function and insulin secretion b Normal glucose levels strengthening secretion c Low blood sugar causing beta-cell recovery 5 How does a reduced incretin effect contribute to diabetes? a Less insulin is released after meals due to diminished incretin signaling b Enhanced beta-cell regeneration after meals c Increased hepatic glucose uptake 6 Which cytokines are implicated in beta-cell stress and dysfunction? a IL-1β and TNF-α promoting inflammation b IFN-γ protecting beta cells c IL-10 causing excessive suppression of insulin 7 What accounting for increased hepatic glucose production in diabetes? a Increased hepatic gluconeogenesis due to insulin resistance b Enhanced hepatic glycolysis reducing glucose output c Decreased glycogen storage causing hypoglycemia 8 What genetic aspect is commonly linked to type 2 diabetes? a Single-gene deficiency causing autoimmune beta destruction b Polygenic risk affecting insulin action and secretion c Monogenic HLA-linked risk 9 What role do ER and oxidative stress play in diabetes pathogenesis? a Reduced oxidative reactions improving function b Beta-cell stress leading to dysfunction and apoptosis c Protective adaptation preventing insulin loss 10 Which pathway best describes beta-cell failure in long-standing diabetes? a Rapid beta-cell regeneration with stable insulin b Immediate immune clearance of beta cells c Chronic stress leads to beta-cell dysfunction and reduced insulin secretion

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Diabetes Mellitus: Pathogenesis Quiz

Froggy Jumps

About this activity

Created by

Download the paper version to play

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Diabetes Mellitus: Pathogenesis QuizOnline version

by Jayaseelan

What is the primary defect in type 2 diabetes pathogenesis?

In type 1 diabetes, what mainly drives beta-cell loss?

What is lipotoxicity in diabetes pathogenesis?

What is glucotoxicity?

How does a reduced incretin effect contribute to diabetes?

Which cytokines are implicated in beta-cell stress and dysfunction?

What accounting for increased hepatic glucose production in diabetes?

What genetic aspect is commonly linked to type 2 diabetes?

What role do ER and oxidative stress play in diabetes pathogenesis?

Which pathway best describes beta-cell failure in long-standing diabetes?